@misc{10481/79064,
year = {2022},
month = {12},
url = {https://hdl.handle.net/10481/79064},
abstract = {Background: Choline and betaine intakes have been related to
cardiovascular health.
Objectives: We aimed to explore the relation between 1-y changes
in dietary intake of choline or betaine and 1-y changes in
cardiometabolic and renal function traits within the frame of the
PREDIMED (PREvención con DIeta MEDiterránea)-Plus trial.
Methods: We used baseline and 1-y follow-up data from 5613
participants (48.2% female and 51.8% male; mean ± SD age:
65.01 ± 4.91 y) to assess cardiometabolic traits, and 3367
participants to assess renal function, of the Spanish PREDIMEDPlus
trial. Participants met ≥3 criteria of metabolic syndrome and
had overweight or obesity [BMI (in kg/m2) ≥27 and ≤40]. These
criteria were similar to those of the PREDIMED parent study.
Dietary intakes of choline and betaine were estimated from the
FFQ.
Results: The greatest 1-y increase in dietary choline or betaine
intake (quartile 4) was associated with improved serum glucose
concentrations (−3.39 and −2.72 mg/dL for choline and betaine,
respectively) and HbA1c levels (−0.10% for quartile 4 of either
choline or betaine intake increase). Other significant changes
associated with the greatest increase in choline or betaine intake
were reduced body weight (−2.93 and −2.78 kg, respectively), BMI
(−1.05 and −0.99, respectively), waist circumference (−3.37 and
−3.26 cm, respectively), total cholesterol (−4.74 and −4.52 mg/dL,
respectively), and LDL cholesterol (−4.30 and −4.16 mg/dL,
respectively). Urine creatinine was reduced in quartile 4 of 1-y
increase in choline or betaine intake (−5.42 and −5.74 mg/dL,
respectively).
Conclusions: Increases in dietary choline or betaine intakes
were longitudinally related to improvements in cardiometabolic
parameters. Markers of renal function were also slightly improved,
and they require further investigation. This trial was registered at
https://www.isrctn.com/ as ISRCTN89898870. Am J Clin Nutr
2022;116:1565–1579.},
organization = {Ministerio de Ciencia e Innovacion through Proyectos de I+D+i "Retos Investigacion"	RTI2018-095569-B-I00	
Ministerio de Ciencia e Innovacion through Programacion Conjunta Internacional	PCI2018-093009},
organization = {European Research Council (ERC)
European Commission	20142019	
340918},
organization = {CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN)},
organization = {Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund	PI13/00673	
PI13/00492	
PI13/00272	
PI13/01123	
PI13/00462	
PI13/00233	
PI13/02184	
PI13/00728	
PI13/01090	
PI13/01056	
PI14/01722	
PI14/00636	
PI14/00618	
PI14/00696	
PI14/01206	
PI14/01919	
PI14/00853	
PI14/01374	
PI14/00972	
PI14/00728	
PI14/01471	
PI16/00473},
organization = {A Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund	PI16/00662	
PI16/01873	
PI16/01094	
PI16/00501	
PI16/00533	
PI16/00381	
PI16/00366	
PI16/01522	
PI16/01120	
PI17/00764	
PI17/01183	
PI17/00855	
PI17/01347	
PI17/00525	
PI17/01827	
PI17/00532	
PI17/00215	
PI17/01441},
organization = {The Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund	PI17/00508	
PI17/01732	
PI17/00926	
PI19/00957	
PI19/00386	
PI19/00309	
PI19/01032	
PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138	
PI20/01532	
PI20/00456	
PI20/00339	
PI20/00557	
PI20/00886	
PI20/01158},
organization = {Especial Action Project "Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus"},
organization = {Recercaixa grant	2013ACUP00194},
organization = {ICREA (Catalan Institution for Research and Advanced Studies) under the ICREA Academia program		
SEMERGEN grant},
organization = {Government of Navarra Department of Health	61/2015},
organization = {Fundacio La Marato de TV3 grant	201630.10},
organization = {AstraZeneca	T2D 2017},
organization = {Junta de Andalucia	PI0458/2013	
PS0358/2016	
PI0137/2018},
organization = {Center for Forestry Research & Experimentation (CIEF)},
organization = {European Commission	PROMETEO/2017/017},
organization = {Balearic Islands Government	35/2011},
organization = {Spanish Ministerio de Ciencia e Innovacion y Ministerio de Universidades Spanish State Research Agency Juan de la Cierva Program	FJC2018-038168-I},
publisher = {Oxford University Press},
keywords = {Choline},
keywords = {Betaine},
keywords = {Mediterranean diet},
keywords = {Cardiovascular disease risk},
keywords = {Cardiometabolic parameters},
keywords = {Renal variables},
title = {One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvención con DIeta MEDiterránea-Plus (PREDIMED-Plus) trial},
doi = {10.1093/ajcn/nqac255},
author = {Díez Ricote, Laura and Bueno Cavanillas, Aurora},
}