@misc{10481/79028,
year = {2022},
month = {11},
url = {https://hdl.handle.net/10481/79028},
abstract = {Introduction: The aim of this study was to describe incidence, incidence trends
and survival patterns of lymphoid neoplasms (LNs) and its subtypes in Spain in
the period 2002-2013 using data from the Spanish Network of Cancer
Registries (REDECAN).
Materials and Methods: Data were extracted from 13 Spanish populationbased
cancer registries. LNs incident cases were codified using the
International Classification of Diseases for Oncology, third edition (ICD-O-3)
and grouped according to the WHO 2008 classification. Age-standardized incidence rates to the 2013 European standard population (ASIRe) were
obtained. Poisson regression models were used to analyze trends in
incidence rates and estimate the annual percentage change (APC) for each
subtype. The number of cases in Spain for 2023 was estimated by applying the
estimated age-specific rates for the year 2023 to the 2023 Spanish population.
Observed survival (OS) was estimated by the Kaplan-Meier method and net
survival (NS) by the Pohar-Perme method. Sex- and age-specific estimates of
5-year NS were calculated, as well as its changes according to two periods of
diagnosis (2002-2007 and 2008-2013).
Results: LNs accounted for 69% (n=39,156) of all hematological malignancies
(n=56,751) diagnosed during the period of study. Median age at diagnosis was 67
years (interquartile range (IQR) = 52-77). The overall ASIRe was 34.23 (95%
confidence interval (CI): 33.89, 34.57) and showed a marked male predominance
in almost all subtypes (global sex ratio = 1.45). During the study period, incidence
trends of LNs remained stable (APC: 0.3; 95% CI: -0.1, 0.6), nevertheless some
subtypes showed statistically significant variations, such as LNs NOS category
(APC: -5.6; 95% CI: -6.8, -4.3). Around 17,926 new cases of LNs will be diagnosed
in 2023 in Spain. Survival rates differed considerably across age-groups, while
they were similar between men and women. Five- year NS was 62.81% (95% CI:
62.1, 63.52) for all LNs, and varied widely across LNs subtypes, ranging from
39.21% to 90.25%. NS for all LNs improved from the first period of diagnosis to
the second one, being 61.57% (95% CI: 60.56, 62.61) in 2002-2007 and 64.17%
(95% CI: 63.29, 65.07) in 2008-2013.
Conclusions: This study presents the first complete and extensive populationbased
analysis of LNs incidence and survival in Spain. These population-based
data provide relevant information to better understand the epidemiology of
LNs in Southern Europe and it features some useful points for public health
authorities and clinicians. However, additional improvements regarding the
registration of these hematological neoplasms can be implemented.},
organization = {Josep Carreras Leukaemia Research Institute	
FIJC1100},
publisher = {Frontiers},
keywords = {Lymphoid neoplasms},
keywords = {Trends},
keywords = {Incidence},
keywords = {Survival},
keywords = {Population-based},
keywords = {Spain},
title = {Incidence and survival of lymphoid neoplasms in Spain, 2002-2013: A population-based study from the Spanish Network of Cancer Registries (REDECAN)},
doi = {10.3389/fonc.2022.1046307},
author = {Pla, Clàudia and Sánchez Pérez, María José and REDECAN working group},
}