@misc{10481/78423,
year = {2022},
month = {11},
url = {https://hdl.handle.net/10481/78423},
abstract = {Background: Selenium is an essential trace mineral with potential interest for cardiovascular
disease (CVD) prevention owing to its antioxidant properties. Epidemiological data on selenium
status and CVD remain inconsistent. The objective of this study was to ascertain whether low
serum selenium (SSe) concentrations are related to an increased risk of a first CVD event in a
population at high cardiovascular risk. Methods: We undertook a case-control study nested within
the “PREvención con DIeta MEDiterránea” (PREDIMED) trial. A total of 207 participants diagnosed
with CVD (myocardial infarction, stroke, or cardiovascular death) during the follow-up period
(2003–2010) were matched by sex, age, and intervention group to 436 controls by incidence density
sampling. Median time between serum sample collection and subsequent CVD event occurrence was
0.94 years. SSe levels were determined using inductively coupled plasma mass spectrometry analysis. Covariates were assessed through validated questionnaires, in-person interviews, and medical record
reviews. Conditional logistic regression was used to calculate multivariable-adjusted odds ratios
(ORs). Results: Among women, the mean SSe concentration was lower in cases than in controls
(98.5  g/L vs. 103.8  g/L; p = 0.016). In controls, SSe levels were directly associated with percentage
of total energy intake from proteins and fish intake (p for linear trend < 0.001 and 0.049, respectively),
whereas SSe concentrations were inversely associated with age, body mass index, and percentage of
total energy intake from carbohydrates (p for linear trend < 0.001, 0.008 and 0.016 respectively). In the
total group, we observed an inverse dose–response gradient between SSe levels and risk of CVD in
the fully-adjusted model (highest vs. lowest quartile: OR = 0.47, 95% CI: 0.27–0.81; ptrend = 0.003).
Conclusions: Among elderly individuals at high cardiovascular risk, high SSe concentrations within
population reference values are associated with lower first CVD incidence.},
organization = {official funding agency for biomedical research of the Spanish government, Instituto de Salud Carlos III (ISCIII)	RTIC G03/140},
organization = {RTIC RD 06/0045 "PREDIMED"	
JR14/00008},
organization = {Spanish government, Instituto de Salud Carlos III (ISCIII), through Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERobn)},
organization = {Centro Nacional de Investigaciones Cardiovasculares	CNIC 06/2007},
organization = {Fondo de Investigacion Sanitaria-Fondo Europeo de Desarrollo Regional (Proyecto de Investigacion)	PI04-2239	
PI05/2584	
CP06/00100	
PI07/0240	
PI07/1138	
PI07/0954	
PI 07/0473	
PI10/01407	
PI10/02658	
PI11/01647	
P11/02505	
PI13/00462},
organization = {Ministry of Science and Innovation, Spain (MICINN)	(AGL)-2009-13906-C02	
AGL2010-22319-C03	
AGL2013-49083C3-1-R},
organization = {Ministerio de Economia y Competitividad-Fondos FEDER-Instituto de Salud Carlos III	UNGR15-CE-3380	
Fundacion Mapfre 2010},
organization = {Junta de Andalucia	PI0105/2007},
organization = {Public Health Division of the Department of Health of the Autonomous Government of Catalonia},
organization = {Center for Forestry Research & Experimentation (CIEF)	GVACOMP 06109	
GVACOMP2010-181	
GVACOMP2011-151	
PROMETEO 21/2021},
organization = {Conselleria de Sanitat y Atencion Primaria	CS2010-AP-111	
CS2011-AP-042},
organization = {Regional Government of Navarra	P27/2011},
organization = {Centre Catala de la Nutricio de l'Institut d'Estudis Catalans},
publisher = {MDPI},
keywords = {Cardiovascular disease},
keywords = {Serum selenium},
keywords = {Older populations},
keywords = {PREDIMED},
keywords = {Mediterranean diet},
title = {Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study},
doi = {10.3390/jcm11226664},
author = {Gutiérrez Bedmar, Mario and Gil Hernández, Fernando and Olmedo Palma, Pablo},
}