@misc{10481/78400,
year = {2022},
month = {11},
url = {https://hdl.handle.net/10481/78400},
abstract = {Resistin is a polypeptide implicated in inflammatory processes, and as such could be
linked to colorectal carcinogenesis. In case-control studies, higher resistin levels have been found
in colorectal cancer (CRC) patients compared to healthy individuals. However, evidence for the
association between pre-diagnostic resistin and CRC risk is scarce. We investigated pre-diagnostic
resistin concentrations and CRC risk within the European Prospective Investigation into Cancer and
Nutrition using a nested case-control study among 1293 incident CRC-diagnosed cases and 1293
incidence density-matched controls. Conditional logistic regression models controlled for matching
factors (age, sex, study center, fasting status, and women-related factors in women) and potential
confounders (education, dietary and lifestyle factors, body mass index (BMI), BMI-adjusted waist
circumference residuals) were used to estimate relative risks (RRs) and 95% confidence intervals (CIs)
for CRC. Higher circulating resistin concentrations were not associated with CRC (RR per doubling
resistin, 1.11; 95% CI 0.94–1.30; p = 0.22). There were also no associations with CRC subgroups
defined by tumor subsite or sex. However, resistin was marginally associated with a higher CRC
risk among participants followed-up maximally two years, but not among those followed-up after
more than two years. We observed no substantial correlation between baseline circulating resistin
concentrations and adiposity measures (BMI, waist circumference), adipokines (adiponectin, leptin),
or metabolic and inflammatory biomarkers (C-reactive protein, C-peptide, high-density lipoprotein
cholesterol, reactive oxygen metabolites) among controls. In this large-scale prospective cohort, there
was little evidence of an association between baseline circulating resistin concentrations and CRC
risk in European men and women.},
organization = {World Health Organization},
organization = {Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London},
organization = {Danish Cancer Society},
organization = {Ligue contre le Cancer (France)},
organization = {Institut Gustave Roussy (France)},
organization = {Mutuelle Generale de l'Education Nationale (France)},
organization = {Institut National de la Sante et de la Recherche Medicale (Inserm)},
organization = {Deutsche Krebshilfe},
organization = {Federal Ministry of Education & Research (BMBF)},
organization = {Hellenic Health Foundation (Greece)},
organization = {Fondazione AIRC per la ricerca sul cancro},
organization = {Consiglio Nazionale delle Ricerche (CNR)},
organization = {Netherlands Government		
Netherlands Government},
organization = {World Cancer Research Fund International (WCRF)},
organization = {Netherlands Government},
organization = {Nordforsk, Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway)},
organization = {Instituto de Salud Carlos III},
organization = {Junta de Andalucia},
organization = {Principality of Asturias},
organization = {Regional Government of Basque Country (Spain)},
organization = {Regional Government of Murcia (Spain)},
organization = {Regional Government of Navarra (Spain)},
organization = {Instituto de Salud Carlos III	RD06/0020},
organization = {Swedish Cancer Society},
organization = {Swedish Scientific Council (Sweden)},
organization = {Regional Government of Skane and Vasterbotten (Sweden)},
organization = {UK Research & Innovation (UKRI)},
organization = {Medical Research Council UK (MRC)},
organization = {Cancer Research UK},
organization = {Netherlands Government},
organization = {Deutsches Krebsforschungszentrum (Germany)		
ERC-2009-AdG 232997},
publisher = {MDPI},
keywords = {Pre-diagnostic resistin},
keywords = {Colorectal cancer},
keywords = {Risk},
keywords = {Prospective},
keywords = {Inflammation},
title = {Pre-Diagnostic Circulating Resistin Concentrations Are Not Associated with Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Study},
doi = {10.3390/cancers14225499},
author = {Pham, Thu Thi and Sánchez Pérez, María José},
}