@misc{10481/78325,
year = {2022},
month = {9},
url = {https://hdl.handle.net/10481/78325},
abstract = {Chronic wounds (resulting from underlying disease, metabolic disorders, infections, trauma, and even tumours)
pose significant health problems. In this work, microparticles, based on polysaccharides (maltodextrin or dextran)
and amino acids, and doped with antibacterial nanoparticles (CuO or ZnO NPs) are designed. Smart nano-inmicroparticles
with a hierarchical 3D structure are developed. The ultimate goal aims at an innovative platform
to achieve skin repair and to manage skin colonization by avoiding infection that could delay and even
impair the healing process. The microparticles are prepared by spray-drying and cross-linked by heating, to obtain
insoluble scaffolds able to facilitate cell proliferation in the wound bed. The nano-in-microparticles are characterized
using a multidisciplinary approach: chemico–physical properties (SEM, SEM-EDX, size distribution,
swelling and degradation properties, structural characterization - FTIR, XRPD, SAXS – mechanical properties,
surface zeta potential) and preclinical properties (in vitro biocompatibility and whole-blood clotting properties,
release studies and antimicrobial properties, and in vivo safety and efficacy on murine burn/excisional wound
model) were assessed. The hierarchical 3D nano-in microparticles demonstrate to promote skin tissue repair in a
preclinical study, indicating that this platform deserves particular attention and further investigation will promote
the prototypes translation to clinics.},
organization = {Horizon 2020 Research and Innovation Programme	814607},
organization = {National Science Foundation (NSF)	DMR-0520547},
organization = {EC Horizon 2020 program under the SINE2020 project},
organization = {ESRF		
654000},
publisher = {Elsevier},
keywords = {Wound healing},
keywords = {Maltodextrin},
keywords = {Dextran},
keywords = {Amino acids},
keywords = {Metal oxide nanoparticles},
keywords = {Microparticles},
keywords = {Antimicrobial properties},
title = {Smart nano-in-microparticles to tackle bacterial infections in skin tissue engineering},
doi = {10.1016/j.mtbio.2022.100418},
author = {Ruggeri, Marco and Sánchez Espejo, Rita María and Viseras Alarcón, César},
}