@misc{10481/78185,
year = {2022},
month = {10},
url = {https://hdl.handle.net/10481/78185},
abstract = {The aim of the present study is to investigate the phytochemical composition of tiger
nut (TN) (Cyperus esculentus L.) and its neuroprotective potential in scopolamine (Scop)-induced
cognitive impairment in rats. The UHPLC-ESI-QTOF-MS analysis enabled the putative annotation of
88 metabolites, such as saccharides, amino acids, organic acids, fatty acids, phenolic compounds and
flavonoids. Treatment with TN extract restored Scop-induced learning and memory impairments. In
parallel, TN extract succeeded in lowering amyloid beta,  -secretase protein expression and acetylcholine
esterase (AChE) activity in the hippocampus of rats. TN extract decreased malondialdehyde
levels, restored antioxidant levels and reduced proinflammatory cytokines as well as the Bax/Bcl2
ratio. Histopathological analysis demonstrated marked neuroprotection in TN-treated groups. In
conclusion, the present study reveals that TN extract attenuates Scop-induced memory impairments
by diminishing amyloid beta aggregates, as well as its anti-inflammatory, antioxidant, anti-apoptotic
and anti-AChE activities.},
organization = {Ministry of Science and Innovation, Spain (MICINN)
Spanish Government	FJC2020-044298-I},
publisher = {MDPI},
keywords = {Cyperus esculentus},
keywords = {Tiger nut},
keywords = {Metabolomics},
keywords = {UHPLC-ESI-QTOF-MS/MS},
keywords = {Foodomics},
keywords = {Scopolamine},
keywords = {Memory impairments},
title = {The Potential Neuroprotective Effect of Cyperus esculentus L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches},
doi = {10.3390/molecules27207118},
author = {Saeed, Marwa M. and Fernández Ochoa, Álvaro and Cádiz Gurrea, María de la Luz and Segura Carretero, Antonio},
}