@misc{10481/78165,
year = {2022},
month = {10},
url = {https://hdl.handle.net/10481/78165},
abstract = {The failure of chemotherapeutic treatment in colorectal cancer (CRC), the second most mortal cancer worldwide, is
associated with several drug limitations, such as non-selective distribution, short half-life, and development of multiple resistances.
One of the most promising strategies in CRC therapy is the development of delivery systems based on nanomaterials that can transport
antitumor agents to the tumor site more efficiently, increasing accumulation within the tumor and thus the antitumor effect. In addition
to taking advantage of the increased permeability and retention effect (EPR) of solid tumors, these nanoformulations can be conjugated
with monoclonal antibodies that recognize molecular markers that are specifically over-expressed on CRC cells. Active targeting of
nanoformulations reduces the adverse effects associated with the cytotoxic activity of drugs in healthy tissues, which will be of interest
for improving the quality of life of cancer patients in the future. This review focuses on in vitro and in vivo studies of drug delivery
nanoformulations functionalized with monoclonal antibodies for targeted therapy of CRC.},
organization = {Ministerio de Educacion y Formacion Profesional (Spain)	FPU17/02977	
FPU19/04112},
organization = {Spanish Government	PI20-00284},
organization = {Junta de Andalucia	A-CTS-666-UGR20	
P20_00540	
B-CTS-122-UGR20	
PYC20-RE-035 UGR},
organization = {European Commission		
Instituto de Salud Carlos III
European Commission	PI19/01478-FEDER},
publisher = {Dove Medical Press},
keywords = {Nanoformulation},
keywords = {Colon carcinoma},
keywords = {Monoclonal antibody},
keywords = {5-fluorouracil},
keywords = {Targeted therapy},
title = {Antibody-Functionalized Nanoformulations for Targeted Therapy of Colorectal Cancer: A Systematic Review},
doi = {10.2147/IJN.S368814},
author = {Cepero Martín, Ana and Luque, Cristina and Cabeza Montilla, Laura and Perazzoli, Gloria and Quiñonero Muñoz, Francisco José and Mesas Hernández, Cristina and Melguizo Alonso, Consolación and Prados Salazar, José Carlos},
}