@misc{10481/78151,
year = {2022},
month = {9},
url = {https://hdl.handle.net/10481/78151},
abstract = {Ethnopharmacological relevance: Serpylli herba extract (SHE), composed of
the aerial parts of wild thyme (Thymus serpyllum L.) (Lamiaceae family), is
traditionally used in Europe and North Africa to treat diarrhea, gastric ulcers,
intestinal parasites and upper respiratory tract infections. Recently, SHE has
generated a great interest for irritable bowel syndrome (IBS) management,
probably due to its intestinal anti-inflammatory properties shown in
experimental colitis and the fact that its active components could preserve
the intestinal barrier integrity, which is altered in patients with IBS.
Aim of study: We aimed to test the effects of a SHE in a rat experimental model
resembling human IBS.
Materials and methods: IBS was provoked by deoxycholic acid (DCA). Rats
were then treated with SHE (100 mg/kg) or gabapentin (70 mg/kg) and different
inflammatory and gut barrier integrity markers were evaluated. Moreover,
several gut hypersensitivity and hyperalgesia determinations were performed.
Results: SHE improved referred pain and visceral hypersensitivity. Additionally, SHE
enhanced immune status by downregulating of the expression of the proinflammatory
mediators Il-1β, Il-6, Ifn-γ, Tlr-4, and the inducible enzyme Cox-2,
thus inducing visceral analgesia, and promoting the restore of the gut barrier
function by upregulating the mucins Muc-2 and Muc-3. These antiinflammatory effects could be related to its action on mast cells since it significantly
inhibited the β-Hexosaminidase production in RBL-2H3 cells. Lastly, SHE also seems
to modulate the serotonin pathway by restoring the altered expression of the 5-HT
receptors Htr-3 and Htr-4.
Conclusion: SHE could be considered a potential new treatment for IBS, since it
ameliorates hypersensitivity, visceral hyperalgesia, and inflammation. These
beneficial effects may be due to the inhibition of mast cells degranulation
and serotonin pathway.},
organization = {Junta de Andalucia	AGR6826	
CTS 164},
organization = {Spanish Government	SAF 2011-29648},
organization = {Instituto de Salud Carlos III},
organization = {European Commission	PI19/01058	
PI20/01447},
publisher = {Frontiers},
keywords = {Serpylli herba},
keywords = {T. serpyllum L.},
keywords = {Intestine anti inflammatory activity},
keywords = {Visceral analgesia},
keywords = {IBS rat model},
title = {Intestinal anti-inflammatory and visceral analgesic effects of a Serpylli herba extract in an experimental model of irritable bowel syndrome in rats},
doi = {10.3389/fphar.2022.967644},
author = {Ruiz Malagón, Antonio Jesús and Rodríguez Sánchez, María José and Rodríguez Sojo, María Jesús and Vezza, Teresa and Algieri, Francesca and Rodríguez Cabezas, María Elena and Rodríguez Nogales, Alba and Gálvez Peralta, Julio Juan},
}