@misc{10481/78096,
year = {2022},
month = {6},
url = {https://hdl.handle.net/10481/78096},
abstract = {Endocrine disrupting chemicals (EDCs) set a public health risk through disruption of normal physiological processes.
The toxicoepigeneticmechanisms of developmental exposure to common EDCs, such as bisphenol A (BPA), are poorly
known. The present study aimed to evaluate associations between perinatal maternal urinary concentrations of BPA,
bisphenol S (BPS) and bisphenol F (BPF) and LINE-1 (long interspersed nuclear elements) and Alu (short interspersed
nuclear elements, SINEs) DNA methylation levels in newborns, as surrogate markers of global DNA methylation. Data
come from 318 mother-child pairs of the `Nutrition in Early Life and Asthma´ (NELA) birth cohort. Urinary bisphenol
concentrationwas measured by dispersive liquid–liquid microextraction and ultrahigh performance liquid chromatography
with tandem mass spectrometry detection. DNA methylation was quantitatively assessed by bisulphite pyrosequencing
on 3 LINEs and 5 SINEs. Unadjusted linear regression analyses showed that higher concentration ofmaternal
urinary BPA in 24th week's pregnancy was associated with an increase in LINE-1 methylation in all newborns (p =
0.01) and, particularly, in male newborns (p = 0.03). These associations remained in full adjusted models [beta =
0.09 (95 % CI = 0.03; 0.14) for all newborns; and beta= 0.10 (95 % CI = 0.03; 0.17) for males], including a non-linear association for female newborns as well (p-trend=0.003). No associations were found between maternal concentrations
of bisphenol and Alu sequences. Our results suggest that exposure to environmental levels of BPA may be
associated with a modest increase in LINE-1 methylation -as a relevant marker of epigenomic stability- during human
fetal development. However, any effects on global DNA methylation are likely to be small, and of uncertain biological
significance.},
organization = {Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Science, Innovation and Universities, Fondos FEDER	MS14/00046	
CP14/00046	
PIE15/00051	
PI16/00422	
FI17/00086	
PI19/00863},
organization = {Fundacion Seneca, Agencia de Ciencia y Tecnologia Region de Murcia	20877/PI/18},
organization = {Ministry of Science and Innovation, Spain (MICINN)},
organization = {Spanish Government	FPU18/01990},
organization = {ISCIII, Spanish Ministry of Science, Innovation and Universities, and Fondos FEDER	MS14/00046	
CPII19/00019},
publisher = {Elsevier},
keywords = {Bisphenol A},
keywords = {DNA methylation},
keywords = {LINE-1},
keywords = {Perinatal exposures},
title = {Maternal urinary concentrations of bisphenol A during pregnancy are associated with global DNA methylation in cord blood of newborns in the “NELA” birth cohort},
doi = {10.1016/j.scitotenv.2022.156540},
author = {Navarro Lafuente, Fuensanta and Fernández Cabrera, Mariana Fátima and Suárez González, Beatriz and NELA Study Group},
}