@misc{10481/78025,
year = {2022},
month = {9},
url = {https://hdl.handle.net/10481/78025},
abstract = {Background: Diets high in acid load may contribute to kidney function
impairment. This study aimed to investigate the association between dietary
acid load and 1-year changes in glomerular filtration rate (eGFR) and urine
albumin/creatinine ratio (UACR).
Methods: Older adults with overweight/obesity and metabolic syndrome
(mean age 65 ± 5 years, 48% women) fromthe PREDIMED-Plus study who had
available data on eGFR (n = 5,874) or UACR (n = 3,639) at baseline and after 1
year of follow-up were included in this prospective analysis. Dietary acid load
was estimated as potential renal acid load (PRAL) and net endogenous acid
production (NEAP) at baseline froma food frequency questionnaire. Linear and
logistic regression models were fitted to evaluate the associations between
baseline tertiles of dietary acid load and kidney function outcomes. One year-
changes in eGFR and UACR were set as the primary outcomes.We secondarily
assessed   10% eGFR decline or  10% UACR increase.
Results: After multiple adjustments, individuals in the highest tertile of
PRAL or NEAP showed higher one-year changes in eGFR (PRAL, b: –
0.64 ml/min/1.73 m2; 95% CI: –1.21 to –0.08 and NEAP, b: –0.56
ml/min/1.73 m2; 95% CI: –1.13 to 0.01) compared to those in the lowest
category. No associations with changes in UACR were found. Participants
with higher levels of PRAL and NEAP had significantly higher odds of
developing  10% eGFR decline (PRAL, OR: 1.28; 95% CI: 1.07–1.54 and
NEAP, OR: 1.24; 95% CI: 1.03–1.50) and  10 % UACR increase (PRAL,
OR: 1.23; 95% CI: 1.04–1.46) compared to individuals with lower dietary
acid load. Conclusions: Higher PRAL and NEAP were associated with worse kidney
function after 1 year of follow-up as measured by eGFR and UACR markers in
an older Spanish population with overweight/obesity andmetabolic syndrome.},
organization = {CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN)},
organization = {Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS)},
organization = {European Commission	PI13/00673	
PI13/00492	
PI13/00272	
PI13/01123	
PI13/00462	
PI13/00233	
PI13/02184	
PI13/00728	
PI13/01090	
PI13/01056	
PI14/01722	
PI14/00636	
PI14/00618	
PI14/00696	
PI14/01206	
PI14/01919	
PI14/00853	
PI14/01374	
PI14/00972	
PI14/00728	
PI14/01471},
organization = {Especial Action Project},
organization = {European Research Council (ERC)
European Commission	340918},
organization = {La Caixa Foundation	2013ACUP00194},
organization = {Junta de Andalucia	PI0458/2013	
PS0358/2016	
PI0137/2018},
organization = {Center for Forestry Research & Experimentation (CIEF)},
organization = {European Commission	PROMETEO/2017/017	
PROMETEO/2021/021	
AICO/2021/347	
2022 FI_B100108},
organization = {SEMERGEN grant},
organization = {Boosting young talent call grant program for the development of IISPV research projects 2019-2021	2019/IISPV/03},
organization = {Societat Catalana d'Endocrinologia i Nutricio (SCEN) Clinical-Research Grant 2019},
organization = {CIBEROBN},
organization = {ICREA under the ICREA Academia programme},
organization = {Generalitat de Catalunya	2022 FI_B100108},
organization = {European Commission	PI16/01522	
PI16/01120	
PI17/00764	
PI17/01183	
PI17/00855	
PI17/01347	
PI17/00525	
PI17/01827	
PI17/00532	
PI17/00215	
PI17/01441	
PI17/00508	
PI17/01732	
PI17/00926	
PI19/00957	
PI19/00386	
PI19/00309	
PI19/01032	
PI19/00576	
PI19/00017	
PI19/01226	
PI19/00781	
PI13/00233	
PI13/02184	
PI13/00728	
PI13/01090	
PI13/01056	
PI14/01722	
PI14/00636	
PI14/00618	
PI14/00696	
PI14/01206	
PI14/01919	
PI14/00853	
PI19/01560	
PI19/01332	
PI20/01802	
PI20/00138	
PI20/01532	
PI20/00456	
PI20/00339	
PI20/00557	
PI20/00886	
PI20/01158	
PI14/01374	
PI14/00972	
PI14/00728	
PI14/01471	
PI16/00473	
PI16/00662	
PI16/01873	
PI16/01094	
PI16/00501	
PI16/00533	
PI16/00381	
PI16/00366},
publisher = {Frontiers},
keywords = {Kidney function},
keywords = {Chronic kidney disease (CKD)},
keywords = {Glomerular filtration rate (GFR)},
keywords = {Net endogenous acid production (NEAP)},
keywords = {Potential renal acid load (PRAL)},
keywords = {Albuminuria},
keywords = {Renal nutrition},
title = {Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome},
doi = {10.3389/fnut.2022.986190},
author = {Valle Hita, Cristina and Bueno Cavanillas, Aurora and Garrido Garrido, Eva María},
}