@misc{10481/77372,
year = {2022},
month = {8},
url = {https://hdl.handle.net/10481/77372},
abstract = {Objectives: More than two years into the COVID-19 pandemic, SARS-CoV-2 still remains a
global public health problem. Successive waves of infection have produced new SARS-CoV-2 variants
with new mutations for which the impact on COVID-19 severity and patient survival is uncertain.
Methods: A total of 764 SARS-CoV-2 genomes, sequenced from COVID-19 patients, hospitalized from
19th February 2020 to 30 April 2021, along with their clinical data, were used for survival analysis.
Results: A significant association of B.1.1.7, the alpha lineage, with patient mortality (log hazard ratio
(LHR) = 0.51, C.I. = [0.14,0.88]) was found upon adjustment by all the covariates known to affect
COVID-19 prognosis. Moreover, survival analysis of mutations in the SARS-CoV-2 genome revealed
27 of them were significantly associated with higher mortality of patients. Most of these mutations
were located in the genes coding for the S, ORF8, and N proteins. Conclusions: This study illustrates
how a combination of genomic and clinical data can provide solid evidence for the impact of viral
lineage on patient survival.},
organization = {Ministry of Science and Innovation, Spain (MICINN)
Spanish Government	PID2020117979RB-I00},
organization = {Instituto de Salud Carlos III
European Commission		
European Commission	IMP/00019},
organization = {Junta de Andalucia	COVID-0012-2020	
PS-2020-342},
organization = {European Social Fund (ESF)	871075},
organization = {Carlos Loucera	PAIDI2020-DOC_00350},
publisher = {MDPI},
keywords = {SARS-CoV-2},
keywords = {COVID-19},
keywords = {Survival},
keywords = {Virus genome},
keywords = {Phylogeny},
title = {Assessing the Impact of SARS-CoV-2 Lineages and Mutations on Patient Survival},
doi = {10.3390/v14091893},
author = {Loucera, Carlos and Ortuño, Francisco M. and Martínez González, Luis Javier and Navarro Marí, José María and De Salazar, Adolfo and Viñuela, Laura and Lepe, José Antonio and García García, Federico and Andalusian COVID-19 Sequencing Initiative},
}