@misc{10481/77191,
year = {2022},
month = {9},
url = {https://hdl.handle.net/10481/77191},
abstract = {The association of obesity with changes in bone mass is not clear. Obese individuals tend
to have an increased bone mineral density, but other studies have shown that obesity is a major
risk factor for fractures. The mechanisms of bone response during a weight loss therapy as well
as the possible osteoprotective effect of exercise should be analyzed. The aim of this study was to
test the effects of a weight-loss program based on the combination of caloric restriction and/or a
mixed training protocol on different parameters of bone morphology and functionality in a DIO rat
model. Three stages were established over a 21-week period (obesity induction 0–12 w, weight loss
intervention 12–15 w, weight maintenance intervention 15–21 w) in 88 male Sprague Dawley rats.
Bone microarchitecture, total mineral and elemental composition, and bone metabolism parameters
were assessed. Weight loss interventions were associated to healthy changes in body composition,
decreasing body fat and increasing lean body mass. On the other hand, obesity was related to a
higher content of bone resorption and inflammatory markers, which was decreased by the weight
control interventions. Caloric restriction led to marked changes in trabecular microarchitecture, with a
significant decrease in total volume but no changes in bone volume (BV). In addition, the intervention
diet caused an increase in trabeculae number and a decrease in trabecular spacing. The training
protocol increased the pore diameter and reversed the changes in cortical porosity and density of
BV induced by the high protein diet at diaphysis level. Regarding the weight-maintenance stage,
diminished SMI values indicate the presence of more plate-like spongiosa in sedentary and exercise
groups. In conclusion, the lifestyle interventions of caloric restriction and mixed training protocol
implemented as weight loss strategies have been effective to counteract some of the deleterious effects
caused by a dietary induction of obesity, specifically in trabecular bone morphometric parameters as
well as bone mineral content.},
organization = {Spanish Government	DEP2014-58296-R	
RTC-2017-6540-1	
RTI2018-100934-B-I00},
organization = {Spanish Ministry of Science, Innovation and Universities through FEDER program},
organization = {European Commission	DEP2014-58296-R	
RTC-2017-6540-1	
RTI2018-100934-B-I00},
organization = {European Union through FEDER program},
publisher = {MDPI},
keywords = {Bone microarchitecture},
keywords = {Micro-CT},
keywords = {Weight loss strategies},
keywords = {Exercise},
keywords = {Caloric restriction diet},
title = {Combination of Caloric Restriction and a Mixed Training Protocol as an Effective Strategy to Counteract the Deleterious Effects in Trabecular Bone Microarchitecture Caused by a Diet-Induced Obesity in Sprague Dawley Rats},
doi = {10.3390/nu14183672},
author = {Nebot, Elena and Martínez Martínez, Rosario and Kapravelou, Garyfallia and Sánchez González, Cristina and Llopis González, Juan and Aranda Ramírez, Pilar and Porres Foulquie, Jesús María and López-Jurado Romero De La Cruz, María},
}