@misc{10481/77123,
year = {2022},
month = {9},
url = {https://hdl.handle.net/10481/77123},
abstract = {Exercise modulates both brown adipose tissue (BAT)metabolismand white
adipose tissue (WAT) browning in murine models. Whether this is true in
humans, however, has remained unknown. An unblinded randomized controlled
trial (ClinicalTrials.gov ID: NCT02365129) was therefore conducted to
study the effects of a 24-week supervised exercise intervention, combining
endurance and resistance training, on BAT volume and activity (primary outcome).
The study was carried out in the Sport and Health University Research
Institute and the Virgen de las Nieves University Hospital of the University of
Granada (Spain). One hundred and forty-five young sedentary adults were
assigned to either (i) a control group (no exercise, n = 54), (ii) a moderate
intensity exercise group (MOD-EX, n = 48), or (iii) a vigorous intensity exercise
group (VIG-EX n = 43) by unrestricted randomization. No relevant adverse
events were recorded. 97 participants (34 men, 63 women) were included in
the final analysis (Control; n = 35, MOD-EX; n=31, and VIG-EX; n=31).We
observed no changes in BAT volume (Δ Control: −22.2 ± 52.6ml; Δ MOD-EX:
−15.5 ± 62.1ml, Δ VIG-EX: −6.8 ± 66.4 ml; P = 0.771) or 18F-fluorodeoxyglucose
uptake (SUVpeak Δ Control: −2.6 ± 3.1ml; Δ MOD-EX: −1.2 ± 4.8, Δ VIG-EX:
−2.2 ± 5.1; p = 0.476) in either the control or the exercise groups. Thus, we did
not find any evidence of an exercise-induced change on BAT volume or activity
in young sedentary adults.},
organization = {Spanish Government	PI13/01393},
organization = {Retos de la Sociedad	DEP2016-79512-R	
PTA-12264I},
organization = {European Commission},
organization = {Spanish Government	FPU13/04365	
FPU14/04172	
FPU15/04059	
FPU16/03653	
FPU19/01609},
organization = {Consejo Nacional de Ciencia y Tecnologia (CONACyT)	440575},
organization = {Fundacion Iberoamericana de Nutricion (FINUT)},
organization = {Redes Tematicas de Investigacion Cooperativa RETIC	Red SAMID RD16/0022},
organization = {AstraZeneca},
organization = {University of Granada Plan Propio de Investigacion 2016 -Excellence actions: Unit of Excellence on Exercise and Health (UCEES)},
organization = {Plan Propio de Investigacion 2018 -Programa Contratos-Puente},
organization = {Programa Perfecionamiento de Doctores},
organization = {Junta de Andalucia		
Consejeria de Conocimiento, Investigacion y Universidades (ERDF)	SOMM17/6107/UGR},
organization = {Junta de Andalucia	P18-RT-4455},
organization = {Fundacion Alfonso Martin Escudero},
organization = {Maria Zambrano fellowship by the Ministerio de Universidades y la Union Europea-NextGenerationEU	RR_C_2021_04},
organization = {Novo Nordisk Foundation},
organization = {Novocure Limited	NNF18OC0032394},
publisher = {Nature},
title = {No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial},
doi = {10.1038/s41467-022-32502-x},
author = {Martínez Téllez, Borja Manuel and Sánchez Delgado, Guillermo and Acosta, Francisco M. and Alcántara Alcántara, Juan Manuel and Amaro Gahete, Francisco José and Martínez Ávila, Wendy D. and Merchán Ramírez, Elisa and Muñoz Hernández, María Victoria and Osuna Prieto, Francisco Javier and Jurado Fasoli, Lucas and Xu, Huiwen and Ortiz Álvarez, Lourdes and Arias Téllez, María José and Méndez Gutiérrez, Andrea and Ortega Porcel, Francisco Bartolomé and Aguilera García, Concepción María and Llamas Elvira, José Manuel and Gil Hernández, Ángel and Ruiz Ruiz, Jonatan},
}