@misc{10481/77013,
year = {2022},
month = {8},
url = {https://hdl.handle.net/10481/77013},
abstract = {Polycyclic aromatic hydrocarbons (PAHs) are among the chemicals with proven impact on
workers’ health. The use of human biomonitoring (HBM) to assess occupational exposure to PAHs has
becomemore common in recent years, but the data generated need an overall viewtomake themmore usable
by regulators and policymakers. This comprehensive review, developed under theHuman Biomonitoring
for Europe (HBM4EU) Initiative,was based on the literature available from2008–2022, aiming to present and
discuss the information on occupational exposure to PAHs, in order to identify the strengths and limitations
of exposure and effect biomarkers and the knowledge needs for regulation in the workplace. The most
frequently used exposure biomarker is urinary 1-hydroxypyrene (1-OH-PYR), ametabolite of pyrene. As
effect biomarkers, those based on the measurement of oxidative stress (urinary 8-oxo-dG adducts) and
genotoxicity (blood DNA strand-breaks) are themost common. Overall, a need to advance newharmonized
approaches both in data and sample collection and in the use of appropriate biomarkers in occupational
studies to obtain reliable and comparable data on PAHexposure in different industrial sectors,was noted.
Moreover, the use of effect biomarkers can assist to identify work environments or activities of high risk,
thus enabling preventive riskmitigation andmanagementmeasures.},
organization = {European Unions' Horizon 2020 research and innovation Programme	733032
HBM4EU},
publisher = {MDPI},
keywords = {Polycyclic aromatic hydrocarbons},
keywords = {Occupational exposure},
keywords = {Human biomonitoring},
keywords = {Exposure biomarker},
keywords = {Effect biomarker},
title = {The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review},
doi = {10.3390/toxics10080480},
author = {Louro, Henriqueta and Fernández Cabrera, Mariana Fátima and Olea Serrano, Nicolás},
}