@misc{10481/77002,
year = {2022},
month = {8},
url = {https://hdl.handle.net/10481/77002},
abstract = {Natural extracellular matrix (ECM) collagen membranes are frequently used for bone regeneration
procedures. Some disadvantages, such as rapid degradation and questionable mechanical
properties, limit their clinical use. These membranes have a heterologous origin and may proceed
from different tissues. Biomineralization is a process in which hydroxyapatite deposits mainly in
collagen fibrils of the matrices. However, when this deposition occurs on the ECM, its mechanical
properties are increased, facilitating bone regeneration. The objective of the present research is to
ascertain if different membranes from distinct origins may undergo biomineralization. Nanomechanical
properties, scanning electron (SEM) and multiphoton (MP) microscopy imaging were performed
in three commercially available ECMs before and after immersion in simulated body fluid solution
for 7 and 21 d. The matrices coming from porcine dermis increased their nanomechanical properties
and they showed considerable mineralization after 21 d, as observed in structural changes detected
through SEM and MP microscopy. It is hypothesized that the more abundant crosslinking and},
organization = {Ministry of Economy and Competitiveness},
organization = {European Commission	PID2020-114694RB-I00	
PID2020-113919RB-I00},
organization = {Ministry of Universities	FPU20/00450},
publisher = {MDPI},
keywords = {Collagen},
keywords = {Membrane},
keywords = {Bone regeneration},
keywords = {Biomineralization},
title = {Biomimetic Remineralization of an Extracellular Matrix Collagen Membrane for Bone Regeneration},
doi = {10.3390/polym14163274},
author = {Osorio Ruiz, Raquel and Asady, Samara and Toledano Osorio, Manuel and Toledano Pérez, Manuel and Osorio Ruiz, María Estrella},
}