@misc{10481/76960,
year = {2022},
month = {7},
url = {https://hdl.handle.net/10481/76960},
abstract = {Multicomponent pharmaceutical materials offer new opportunities to address drug physicochemical
issues and to obtain improved drug formulation, especially on oral administration drugs.
This work reports three new multicomponent pharmaceutical crystals of the non-steroidal antiinflammatory
drug diclofenac and the nucleobases adenine, cytosine, and isocytosine. They have
been synthesized by mechanochemical methods and been characterized in-depth in solid-state by
powder and single crystal X-ray diffraction, as well as other techniques such as thermal analyses
and infrared spectroscopy. Stability and solubility tests were also performed on these materials. This
work aimed to evaluate the physicochemical properties of these solid forms, which revealed thermal
stability improvement. Dissociation of the new phases was observed in water, though. This fact is
consistent with the reported observed layered structures and BFDH morphology calculations.},
organization = {Spanish Agencia Estatal de Investigacion of the Ministerio de Ciencia, Innovacion y Universidades (MICIU)},
organization = {European Commission	PGC2018-102047-B-I00},
organization = {FEDER-Universidad de Granada, Spain	B-FQM-478-UGR20},
publisher = {MDPI},
keywords = {Diclofenac},
keywords = {Nucleobases},
keywords = {Mechanochemical synthesis},
keywords = {Multicomponent materials},
keywords = {Pharmaceutical solid forms},
title = {Towards the Development of Novel Diclofenac Multicomponent Pharmaceutical Solids},
doi = {10.3390/cryst12081038},
author = {Acebedo Martínez, Francisco Javier and Alarcón Payer, Carolina and Barrales Ruiz, Helena María and Niclos Gutiérrez, Juan and Domínguez Martín, Alicia and Choquesillo Lazarte, Duane},
}