@misc{10481/76946,
year = {2022},
month = {8},
url = {https://hdl.handle.net/10481/76946},
abstract = {Oleanolic acid (OA) is a natural triterpene widely found in olive leaves that possesses
antioxidant, anti-inflammatory, and insulin-sensitizing properties, among others. These OA characteristics
could be of special interest in the treatment and prevention of insulin resistance (IR), but
greater in-depth knowledge on the pathways involved in these properties is still needed. We aimed
to systematically review the effects of OA on the molecular mechanisms and signaling pathways
involved in the development of IR and underlying oxidative stress in insulin-resistant animal models
or cell lines. The bibliographic search was carried out on PubMed, Web of Science, Scopus, Cochrane,
and CINHAL databases between January 2001 and May 2022. The electronic search produced
5034 articles but, after applying the inclusion criteria, 13 animal studies and 3 cell experiments were
identified, using SYRCLE’s Risk of Bias for assessing the risk of bias of the animal studies. OA was
found to enhance insulin sensitivity and glucose uptake, and was found to suppress the hepatic
glucose production, probably by modulating the IRS/PI3K/Akt/FoxO1 signaling pathway and by
mitigating oxidative stress through regulating MAPK pathways. Future randomized controlled
clinical trials to assess the potential benefit of OA as new therapeutic and preventive strategies for IR
are warranted.},
organization = {Andalusia 2014-2020 European Regional Development Fund (ERDF) Operative Program	B-AGR-287-UGR18},
publisher = {MDPI},
keywords = {Olea europaea},
keywords = {Bioactive compounds},
keywords = {Triterpenes},
keywords = {Oleanolic acid},
keywords = {Insulin resistance},
keywords = {Type 2 diabetes mellitus},
keywords = {Oxidative stress},
keywords = {Inflammation},
keywords = {Insulin signaling},
keywords = {Pathways},
title = {Potential Molecular Targets of Oleanolic Acid in Insulin Resistance and Underlying Oxidative Stress: A Systematic Review},
doi = {10.3390/antiox11081517},
author = {Fernández Aparicio, Ángel and Correa Rodríguez, María and Schmidt Río Valle, Jacqueline and González Jiménez, Emilio},
}