@misc{10481/76913,
year = {2022},
month = {8},
url = {https://hdl.handle.net/10481/76913},
abstract = {Purpose Metabolic flexibility (MetF), which is a surrogate of metabolic health, can be assessed by the change in the respiratory
exchange ratio (RER) in response to an oral glucose tolerance test (OGTT). We aimed to determine the day-to-day
reproducibility of the energy expenditure (EE) and RER response to an OGTT, and whether a simulation-based postcalorimetric
correction of metabolic cart readouts improves day-to-day reproducibility.
Methods The EE was assessed (12 young adults, 6 women, 27 ± 2 years old) using an Omnical metabolic cart (Maastricht
Instruments, Maastricht, The Netherlands) after an overnight fast (12 h) and after a 75-g oral glucose dose on 2 separate
days (48 h). On both days, we assessed EE in 7 periods (one 30-min baseline and six 15-min postprandial). The ICcE was
performed immediately after each recording period, and capillary glucose concentration (using a digital glucometer) was
determined.
Results We observed a high day-to-day reproducibility for the assessed RER (coefficients of variation [CV] < 4%) and EE
(CVs < 9%) in the 7 different periods. In contrast, the RER and EE areas under the curve showed a low day-to-day reproducibility
(CV = 22% and 56%, respectively). Contrary to our expectations, the postcalorimetric correction procedure did
not influence the day-to-day reproducibility of the energy metabolism response, possibly because the Omnical’s accuracy
was ~ 100%.
Conclusion Our study demonstrates that the energy metabolism response to an OGTT is poorly reproducible (CVs > 20%)
even using a very accurate metabolic cart. Furthermore, the postcalorimetric correction procedure did not influence the
day-to-day reproducibility.},
organization = {Spanish Ministry of Economy and Competitiveness via Retos de la Sociedad grant	DEP2016-79512-R},
organization = {European Commission},
organization = {Spanish Government	FPU15/04059	
FPU19/01609},
organization = {University of Granada Plan Propio de Investigacion 2016-Excellence actions: Unit of Excellence on Exercise and Health},
organization = {Junta de Andalucia, Consejeria de Conocimiento, Investigacion y Universidades via the ERDF	SOMM17/6107/UGR},
organization = {Fundacion Alfonso Martin Escudero},
organization = {Universidad de Granada/CBUA},
publisher = {Springer},
keywords = {Indirect calorimetry},
keywords = {Reliability},
keywords = {Postprandial metabolism},
keywords = {Glucose tolerance},
keywords = {Metabolic cart},
title = {Reproducibility of the energy metabolism response to an oral glucose tolerance test: influence of a postcalorimetric correction procedure},
doi = {10.1007/s00394-022-02986-w},
author = {Alcántara Alcántara, Juan Manuel and Sánchez Delgado, Guillermo and Jurado Fasoli, Lucas and Ruiz Ruiz, Jonatan},
}