@misc{10481/76874,
year = {2022},
month = {8},
url = {https://hdl.handle.net/10481/76874},
abstract = {SARS-CoV-2 infection can cause an inflammatory syndrome (COVID-19) leading,
in many cases, to bilateral pneumonia, severe dyspnea, and in ~5% of these,
death. DNAmethylation is known to play an important role in the regulation of
the immune processes behind COVID-19 progression, however it has not been
studied in depth. In this study, we aim to evaluate the implication of DNA
methylation in COVID-19 progression by means of a genome-wide DNA
methylation analysis combined with DNA genotyping. The results reveal the
existence of epigenomic regulation of functional pathways associated with
COVID-19 progression andmediated by genetic loci.We find an environmental
trait-related signature that discriminatesmild from severe cases and regulates,
among other cytokines, IL-6 expression via the transcription factor CEBP. The
analyses suggest that an interaction between environmental contribution,
genetics, and epigenetics might be playing a role in triggering the cytokine
storm described in the most severe cases.},
organization = {Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades of the regional government of Andalucia},
organization = {European Union through European Regional Development Fund	CV20-10150},
organization = {Consejo Superior de Investigaciones cientificas	CSIC-COV19-016/202020E155},
organization = {Junta de Castilla y Leon	COVID 07.04.467B04.74011.0},
organization = {Consejeria de Salud y Familias of the regional government of Andalucia	PECOVID-0072-2020},
organization = {Instituto de Salud Carlos III (ISCIII, Spanish Health Ministry) through the Sara Borrell subprogram	CD18/00153},
organization = {Programa Estrategico Instituto de Biologia y Genetica Molecular, IBGM excellence programme	CLU-2029-02
CCVC8485},
publisher = {Nature},
title = {Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection},
doi = {10.1038/s41467-022-32357-2},
author = {Barturen, Guillermo and Carnero Montoro, Elena and Martínez Bueno, Manuel and Alcántara Domínguez, Clara and Alarcón Riquelme, Marta Eugenia},
}