@misc{10481/76707,
year = {2022},
month = {7},
url = {http://hdl.handle.net/10481/76707},
abstract = {Background and purpose: Melatonin has shown beneficial effects on obesity, both in humans and experimental
models, via regulating the altered circadian rhythm and thus ameliorating the gut dysbiosis associated with this
metabolic condition. However, its clinical use is limited, mostly due to its short half-life. Agomelatine is an
agonist of the melatonin receptors that could be used to manage obesity and offer a better profile than melatonin.
Experimental approach: Male C57BL/6 mice were fed a high fat diet and orally treated for five weeks with agomelatine,
or melatonin or metformin, used as control drugs. Metabolic profile, inflammatory status, vascular
dysfunction and intestinal microbiota composition were assessed.
Key results: Agomelatine lessened body weight gain, enhanced glucose and lipid metabolisms, and improved
insulin resistance. It also reduced the obesity-associated inflammatory status and endothelial dysfunction,
probably linked to its effect on gut dysbiosis, consisting of the restoration of bacterial populations with key
functions, such as short chain fatty acid production.
Conclusions and implications: Agomelatine can be considered as a novel therapeutic tool for the management of
human obesity and its associated comorbidities.},
organization = {Junta de Andalucia	CTS 164},
organization = {Instituto de Salud Carlos III},
organization = {European Commission	PI19/01058	
European Commission},
publisher = {Elsevier},
keywords = {Agomelatine},
keywords = {Melatonin},
keywords = {Metabolism},
keywords = {Metformin},
keywords = {Microbiome},
keywords = {Obesity},
title = {The melatonergic agonist agomelatine ameliorates high fat diet-induced obesity in mice through the modulation of the gut microbiome},
doi = {10.1016/j.biopha.2022.113445},
author = {Díez Echave, Patricia and Vezza, Teresa and Algieri, Francesca and Ruiz Malagón, Antonio Jesús and Hidalgo García, Laura and García García, Federico and Morón Romero, María Rocío and Sánchez Santos, Manuel and Toral, Marta and Romero Pérez, Miguel and Duarte Pérez, Juan Manuel and Garrido Mesa, José and Rodríguez Cabezas, María Elena and Rodríguez Nogales, Alba and Gálvez Peralta, Julio Juan},
}