@misc{10481/76688,
year = {2022},
month = {6},
url = {http://hdl.handle.net/10481/76688},
abstract = {Objective: To evaluate the effect of Non-alcoholic fatty liver disease (NAFLD) status in the
impact of lifestyle over Health-related quality of life (HRQoL) in patients with metabolic
syndrome (MetS).
Methods: Baseline and 1 year follow up data from the PREDIMED-plus cohort (men and
women, 55-75 years old with overweight/obesity and MetS) were studied. Adherence to
an energy-restricted Mediterranean Diet (er-MeDiet) and Physical Activity (PA) were
assessed with a validated screeners. Hepatic steatosis index (HSI) was implemented to
evaluate NAFLD while the SF-36 questionnaire provided HRQoL evaluation. Statistical
analyses were performed to evaluate the influence of baseline NAFLD on HRQoL as
affected by lifestyle during 1 year of follow up.
Results: Data from 5205 patients with mean age of 65 years and a 48% of female
participants. Adjusted linear multivariate mixed regression models showed that patients
with lower probability of NAFLD (HSI < 36 points) were more responsive to er-MeDiet (b
0.64 vs b 0.05 per er-MeDiet adherence point, p< 0.01) and PA (b 0.05 vs b 0.01 per
MET-h/week, p = 0.001) than those with high probability for NAFLD in terms Physical SF-
36 summary in the 1 year follow up. 10 points of er-MeDiet adherence and 50 MET-h/
week were thresholds for a beneficial effect of lifestyle on HRQoL physical domain in
patients with lower probability of NAFLD.
Conclusion: The evaluation of NAFLD by the HSI index in patients with MetS might
identify subjects with different prospective sensitivity to lifestyle changes in terms of
physical HRQoL (http://www.isrctn.com/ISRCTN89898870).},
organization = {CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN)},
organization = {Instituto de Salud Carlos III (ISCIII) through the Fondo de Investigacion para la Salud (FIS)},
organization = {European Commission	PI13/00673	
PI13/00492	
PI13/00272	
PI13/01123	
PI13/00462	
PI13/00233	
PI13/02184	
PI13/00728	
PI13/01090	
PI13/01056	
PI14/01722	
PI14/00636	
PI14/00618	
PI14/00696	
PI14/01206	
PI14/01919	
PI14/00853	
PI14/01374	
PI14/00972	
PI14/00728	
PI14/01471	
PI16/00473	
PI16/00662	
PI16/01873	
PI16/01094	
PI16/00501	
PI16/00533	
PI16/00381	
PI16/00366	
PI16/01522	
PI16/01120	
PI17/00764	
PI17/01183	
PI17/00855	
PI17/01347	
PI17/00525	
PI17/01827	
PI17/00532	
PI17/00215	
PI17/01441	
PI17/00508	
PI17/01732	
PI17/00926	
PI19/00957	
PI19/00386	
PI19/00309	
PI19/01032	
PI19/00576	
PI19/00017	
PI19/01226	
PI19/00781	
PI19/01560	
PI19/01332	
PI20/01802	
PI20/00138	
PI20/01532	
PI20/00456	
PI20/00339	
PI20/00557	
PI20/00886	
PI20/01158},
organization = {Special Action Project "Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus"},
organization = {La Caixa Foundation	2013ACUP00194},
organization = {Junta de Andalucia	PI0458/2013	
PS0358/2016	
PI0137/2018},
organization = {SEMERGEN grant},
organization = {Department of Health of the Government of Navarra	61/201},
organization = {Fundacio La Marato de TV	201630.10},
organization = {European Research Council (ERC)
European Commission	340918},
organization = {Ministerio de Ciencia e Investigacion	RTI2018-095569-B-I00	
PCI2018-093009	
35/2011},
publisher = {Frontiers},
keywords = {NAFLD},
keywords = {Metabolic syndrome},
keywords = {Mediterranean diet},
keywords = {Physical activity},
keywords = {HRQoL},
title = {Role of NAFLD on the Health Related QoL Response to Lifestyle in Patients With Metabolic Syndrome: The PREDIMED Plus Cohort},
doi = {10.3389/fendo.2022.868795},
author = {Martínez Urbistondo, Diego and Bueno Cavanillas, Aurora},
}