@misc{10481/76661,
year = {2022},
month = {7},
url = {http://hdl.handle.net/10481/76661},
abstract = {Sjögren’s disease is a complex autoimmune disease with twelve established susceptibility
loci. This genome-wide association study (GWAS) identifies ten novel genome-wide significant
(GWS) regions in Sjögren’s cases of European ancestry: CD247, NAB1, PTTG1-
MIR146A, PRDM1-ATG5, TNFAIP3, XKR6, MAPT-CRHR1, RPTOR-CHMP6-BAIAP6, TYK2,
SYNGR1. Polygenic risk scores yield predictability (AUROC = 0.71) and relative risk of 12.08.
Interrogation of bioinformatics databases refine the associations, define local regulatory
networks of GWS SNPs from the 95% credible set, and expand the implicated gene list to
>40. Many GWS SNPs are eQTLs for genes within topologically associated domains in
immune cells and/or eQTLs in the main target tissue, salivary glands.},
organization = {United States Department of Health & Human Services
National Institutes of Health (NIH) - USA	HHSN268200782096C	
HHSN268201100011I	
HHSN268201200008I	
R01AR073855	
R01AR065953	
R01AR074310	
P50AR060804	
R01AR050782	
R01DE018209	
R33AR076803	
R21AR079089},
organization = {NIDCR Sjogren's Syndrome Clinic		
NIDCR Division of Intramural Research at the National Institutes of Health funds	Z01-DE000704},
organization = {German Research Foundation (DFG)	EXC 2155	
390874280},
organization = {Research Council of Norway	240421	
316120},
organization = {Western Norway Regional Health Authority (Helse Vest)	911807	
912043},
organization = {Swedish Research Council for Medicine and Health		
Swedish Rheumatism Association		
King Gustav V's 80-year Foundation		
Swedish Society of Medicine		
Swedish Cancer Society},
organization = {Sjogren's Syndrome Foundation		
Phileona Foundation		
Stockholm County Council		
Swedish Research Council},
organization = {European Commission	2017-000641},
organization = {Assistance Publique-Hopitaux de Paris (Ministry of Health)	P060228},
organization = {French society of Rheumatology},
organization = {United States Department of Health & Human Services
National Institutes of Health (NIH) - USA
NIH National Institute on Aging (NIA)	RC2 AG036495	
RC4 AG039029	
United States Department of Health & Human Services
National Institutes of Health (NIH) - USA
NIH National Institute of Dental & Craniofacial Research (NIDCR)		
United States Department of Health & Human Services
National Institutes of Health (NIH) - USA
NIH National Eye Institute (NEI)		
United States Department of Health & Human Services
National Institutes of Health (NIH) - USA
NIH Office of Research on Women's Health (ORWH)	N01-DE-32636	
NIDCR through CIDR's NIH contract},
publisher = {Nature},
title = {Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells},
doi = {10.1038/s41467-022-30773-y},
author = {Khatri, Bhuwan and Martín Ibáñez, Javier and Teruel, María and Alarcón Riquelme, Marta Eugenia and PRECISESADS Clinical Consortium and Sjogrens Int Collaborative Clinica and UK Primary Sjogrens Syndrome Regis},
}