@misc{10481/76564,
year = {2022},
month = {7},
url = {http://hdl.handle.net/10481/76564},
abstract = {Lifestyle changes are causing an exponential increase in the prevalence of obesity and
metabolic syndrome (MetS) worldwide. The most frequent complications of these are the development
of diabetes (T2D) and cardiovascular disease (CVD). Accurate tools are needed to classify the
cardiovascular risk (CVR) in the MetS population. In recent years, numerous biomarkers of bone
metabolism have been associated with CVR. The aim of this study was to determine the levels of
undercarboxylated osteocalcin (ucOC) in a cohort of patients with MetS and to analyse its association
with MetS parameters and CVR as well as with T2D prevalence. A longitudinal study was
conducted in which a MetS population was followed for one year. Weight change, adherence to the
Mediterranean diet (MedDiet), ucOC levels, MetS parameters and CVR were analysed and CVR was
calculated using different scores. Our results showed a decrease of CVR associated with a better
adherence to the MetDiet resulting in higher HDL-C and ucOC levels though the improvement of
MetS risk factors. This bone protein appeared as a potential biomarker to classify CVR in the MetS
population, especially for MetS patients without prevalent T2D. Furthermore, ucOC serum levels
could be good predictors of T2D prevalence.},
organization = {Instituto de Salud Carlos III
European Commission	PI18-00803	
PI21/01069	
PI18-01235	
FI19/00118	
CD20/00022},
organization = {European Commission},
organization = {Junta de Andalucia	CD20/00022	
PI-0268-2019	
RH-00692021},
publisher = {MDPI},
keywords = {Metabolic syndrome},
keywords = {Cardiovascular risk},
keywords = {Diabetes},
keywords = {Osteocalcin},
keywords = {Mediterranean diet},
title = {Undercarboxylated Osteocalcin: A Promising Target for Early Diagnosis of Cardiovascular and Glycemic Disorders in Patients with Metabolic Syndrome: A Pilot Study},
doi = {10.3390/nu14142991},
author = {Riquelme Gallego, Blanca and García Molina, Laura and Cano Ibáñez, Naomi and Andújar Vera, Francisco Luis and González Salvatierra, Sheila and García Fontana, Cristina and Bueno Cavanillas, Aurora and Muñoz Torres, Manuel Eduardo and García Fontana, Beatriz},
}