@misc{10481/76488,
year = {2022},
month = {7},
url = {http://hdl.handle.net/10481/76488},
abstract = {Background: Prior evidence suggests that capsinoids ingestion may
increase resting energy expenditure (EE) and fat oxidation (FATox), yet
whether they can modulate those parameters during exercise conditions
remains poorly understood. We hypothesized that dihydrocapsiate
(DHC) ingestion would increase EE and specifically FATox during an
acute bout of aerobic exercise at FATmax intensity (the intensity that
elicits maximal fat oxidation during exercise [MFO]) in men with overweight/
obesity. Since FATmax and MFO during aerobic exercise
appear to be indicators of metabolic flexibility, whether DHC has an
impact on FATox in this type of population is of clinical interest.
Methods: A total of 24 sedentary men (age = 40.2 ± 9.2 years-old;
body mass index = 31.6 ± 4.5 kg/m2 [n = 11 overweight, n = 13
obese]) participated in this randomized, triple-blinded, placebocontrolled,
crossover trial (registered under ClinicalTrials.gov
Identifier no. NCT05156697). On the first day, participants underwent
a submaximal exercise test on a cycle ergometer to determine their MFO and FATmax intensity during exercise. After 72 hours had
elapsed, the participants returned on 2 further days (≥ 72 hours
apart) and performed a 60 min steady-state exercise bout (i.e. cycling
at their FATmax, constant intensity) after ingesting either 12 mg of
DHC or placebo; these conditions were randomized. Respiratory gas
exchange was monitored by indirect calorimetry. Serum marker
concentrations (i.e. glucose, triglycerides, non-esterified fatty acids
(NEFAs), skin temperature, thermal perception, heart rate, and perceived
fatigue) were assessed.
Results: There were no significant differences (P > 0.05) between
DHC and placebo conditions in the EE and FATox during exercise.
Similarly, no significant changes were observed in glucose, triglycerides,
or NEFAs serum levels, neither in the skin temperature nor
thermal perception across conditions. Heart rate and perceived
fatigue did not differ between conditions.
Conclusions: DHC supplementation does not affect energy metabolism
during exercise in men with overweight/obesity.},
organization = {Spanish Junta de Andalucia via Consejeria de Conocimiento, Investigacion y Universidades, Proyectos I+D+i del Programa Operativo del Fondo Europeo de Desarrollo Regional (FEDER 2018)	B.CTS.377.UGR18},
organization = {Spanish Government	PTA 12264-I	
FPU16/02828	
FPU16/05159},
publisher = {Taylor & Francis},
keywords = {Capsinoids},
keywords = {TRPV1},
keywords = {Obesity},
keywords = {Nutraceutical},
keywords = {FATmax},
keywords = {Metabolism},
title = {Dihydrocapsiate does not increase energy expenditure nor fat oxidation during aerobic exercise in men with overweight/ obesity: a randomized, triple-blinded, placebo-controlled, crossover trial},
doi = {10.1080/15502783.2022.2099757},
author = {Osuna Prieto, Francisco Javier and Acosta, Francisco M. and Pérez de Arrilucea Le Floc'h, Unai A. and Riquelme Gallego, Blanca and Merchán Ramírez, Elisa and Xu, Huiwen and Cruz Márquez, Juan Carlos De La and Amaro Gahete, Francisco José and Llamas Elvira, José Manuel and Triviño Ibáñez, Eva María and Segura Carretero, Antonio and Ruiz Ruiz, Jonatan},
}