@misc{10481/76470,
year = {2022},
month = {6},
url = {http://hdl.handle.net/10481/76470},
abstract = {Purpose: Brown adipose tissue (BAT) increases metabolic heat production in response to cold exposure. Body size
and composition are involved in the human cold response, yet the influence of BAT herein have not fully been
explored. Here, we aimed to study the association of the cold-induced shivering threshold time with body
composition, BAT, the perception of shivering and skin temperature in young adults.
Methods: 110 young healthy adults (81 females; age = 21.7 ± 2.1 years, BMI = 24.2 ± 4.3 kg/m2) underwent 2 h
of individualized cooling, followed by the quantification of BAT using a18F-fluorodeoxyglucose ([18F]FDG)
positron emission tomography-computed tomography (PET-CT) scan. Body mass index (BMI), lean mass, fat mass
and body surface area (BSA) were also measured. Shivering threshold time was defined as the time until shivering
occurred using an individualized cooling protocol.
Results: The shivering threshold time was on average 116.1 min for males and 125.8 min for females, and was
positively associated to BMI (β = 3.106; R2 = 0.141; p = 0.001), lean mass (β = 2.295; R2 = 0.128; p = 0.001)
and fat mass (β = 1.492; R2 = 0.121; p = 0.001) in females, but not in males (all p ≥ 0.409). The shivering
threshold time was positively associated with BSA in males (p = 0.047) and females (p = 0.001), but it was not
associated with BAT volume or [18F]FDG uptake nor with the perception of shivering and skin temperature
perception in both sexes.
Conclusion: The shivering threshold time is positively associated with whole-body adiposity and lean mass in
females, but not in males. The shivering threshold time was positively associated with BSA, but no association
was observed with BAT nor with the perception of shivering or skin temperature. Future research should consider
the influence of body composition when applying cooling protocols among individuals with different phenotypical
features.},
organization = {Spanish Government	PI13/01393	
PTA 12264-I},
organization = {Retos de la Sociedad	DEP 2016-79512-R},
organization = {European Commission},
organization = {Spanish Government	FPU 13/03410},
organization = {Fundacion Iberoamericana de Nutricion (FINUT)},
organization = {Redes Tematicas de Investigacion Cooperativa RETIC	Red SAMID RD16/0022},
organization = {AstraZeneca},
organization = {University of Granada Plan Propio de Investigacion 2016 - Excellence actions: Unit of Excellence on Exercise and Health (UCEES)},
organization = {Plan Propio de Investigacion 2018: Programa ContratosPuente},
organization = {Junta de Andalucia, Consejeria de Conocimiento, Investigacion y Universidades (ERDF)	SOMM17/6107/UGR},
organization = {Fundacion Carolina	C.2016-574,961},
organization = {Fundacion Alfonso Martin Escudero},
organization = {Ministerio de Universidades y la Union Europea-NextGenerationEU	RR_C_2021_04},
publisher = {Elsevier},
keywords = {Brown fat},
keywords = {Cold perception},
keywords = {Shivering time},
keywords = {Thermogenesis},
title = {Association of shivering threshold time with body composition and brown adipose tissue in young adults},
doi = {10.1016/j.jtherbio.2022.103277},
author = {Sardjoe Mishre, Aashley S. D. and Martínez Téllez, Borja Manuel and Acosta, Francisco M. and Sánchez Delgado, Guillermo and Ruiz Ruiz, Jonatan},
}