@misc{10481/76419,
year = {2022},
month = {6},
url = {http://hdl.handle.net/10481/76419},
abstract = {Background: The links of sedentary behavior and physical activity with health outcomes
in children and adolescents is well known. However, the molecular mechanisms involved
are poorly understood.We aimed to synthesize the current knowledge of the association
of sedentary behavior and physical activity (acute and chronic effects) with gene
expression and epigenetic modifications in children and adolescents.
Methods: PubMed, Web of Science, and Scopus databases were systematically
searched until April 2022. A total of 15 articles were eligible for this review. The risk of
bias assessment was performed using the Joanna Briggs Institute Critical Appraisal Tool
for Systematic Reviews and/or a modified version of the Downs and Black checklist.
Results: Thirteen studies used candidate gene approach, while only 2 studies
performed high-throughput analyses. The candidate genes significantly linked to
sedentary behavior or physical activity were: FOXP3, HSD11B2, IL-10, TNF-a, ADRB2,
VEGF, HSP70, SOX, and GPX. Non-coding Ribonucleic acids (RNAs) regulated by
sedentary behavior or physical activity were: miRNA-222, miRNA-146a, miRNA-16,
miRNA-126, miR-320a, and long non-coding RNA MALAT1. These molecules are
involved in inflammation, immune function, angiogenic process, and cardiovascular
disease. Transcriptomics analyses detected thousands of genes that were altered
following an acute bout of physical activity and are linked to gene pathways related
to immune function, apoptosis, and metabolic diseases.
Conclusion: The evidence found to date is rather limited. Multidisciplinary studies
are essential to characterize the molecular mechanisms in response to sedentary
behavior and physical activity in the pediatric population. Larger cohorts and randomized controlled trials, in combination with multi-omics analyses, may provide the necessary
data to bring the field forward.},
organization = {Spanish Government	DEP2013-47540	
DEP2016-79512-R	
DEP2017-91544-EXP},
organization = {European Commission	RYC-2016-21199	
ENDORE SAF2017-87526-R	
09/UPB/19	
45/UPB/20	
27/UPB/21	
SOMM17/6107/UGR},
organization = {Spanish Government	B-CTS-355	
UGR18},
organization = {United States Department of Health & Human Services},
organization = {National Institutes of Health (NIH) - USA	B-CTS-500-UGR18},
organization = {PERC Systems Biology Fund},
organization = {Huawei Technologies},
organization = {EXERNET Research Network on Exercise and Health	A-CTS-614-UGR20	
FPU 16/02760	
FPU19/05561},
organization = {UO1 TR002004},
organization = {Alicia Koplowitz Foundation},
organization = {University of Granada},
organization = {Junta de Andalucia, Consejeria de Conocimiento, Investigacion y Universidades and European Regional},
organization = {Development Fund (ERDF)	DEP2005- 00046/ACTI	
Junta de Andalucia	PAIDI P20_00158},
publisher = {Frontiers},
keywords = {Exercise},
keywords = {Methylation},
keywords = {Omics},
keywords = {Physical fitness},
keywords = {RNA-seq},
keywords = {Epigenomics},
title = {Transcriptional and Epigenetic Response to Sedentary Behavior and Physical Activity in Children and Adolescents: A Systematic Review},
doi = {10.3389/fped.2022.917152},
author = {Plaza Florido, Abel Adrián and Pérez Prieto, Inmaculada and Molina García, Pablo and Ortega Porcel, Francisco Bartolomé and Altmae, Signe},
}