@misc{10481/76094,
year = {2020},
month = {12},
url = {http://hdl.handle.net/10481/76094},
abstract = {BACKGROUND & AIMS: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/
American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures
of adherence to these guidelines and tested their associations with colorectal cancer
risk in the European Prospective Investigation into Cancer and Nutrition cohort. METHODS: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated
from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery
set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition
participants with metabolomics data. Partial least-squares regression was used to derive fatty
acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent
set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and
95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and
per the corresponding change in metabolic signatures using multivariable conditional logistic
regression.
RESULTS: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain
fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated
more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI,
0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the
WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations
were stronger in male compared with female participants.
CONCLUSIONS: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or
biological risk factors were associated with colorectal cancer. Measuring a specific panel of
metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population
at higher risk of colorectal cancer.},
organization = {World Cancer Research Fund International (WCRF)	20131002},
organization = {European Commission grant EU-FP7/BBMRI-LPC	313010},
organization = {International Agency for Research on Cancer},
organization = {Danish Cancer Society},
organization = {Ligue Contre le Cancer (France)},
organization = {General Electric},
organization = {Institut Gustave-Roussy (France)},
organization = {Mutuelle Generale de l'Education Nationale (France)},
organization = {Institut National de la Sante et de la Recherche Medicale (Inserm)},
organization = {Deutsche Krebshilfe		
German Cancer Research Center (Germany)		
Federal Ministry of Education & Research (BMBF)		
Deutsche Krebshilfe},
organization = {Hellenic Health Foundation (Greece)},
organization = {Fondazione AIRC per la ricerca sul cancro},
organization = {Consiglio Nazionale delle Ricerche (CNR)},
organization = {Dutch Ministry of Public Health, Welfare and Sports (The Netherlands)		
Netherlands Cancer Registry (The Netherlands)		
Netherlands Government},
organization = {Nordic Centre of Excellence Programme on Food, Nutrition and Health (Norway)},
organization = {Instituto de Salud Carlos III	PI13/00061	
PI13/01162},
organization = {Junta de Andalucia},
organization = {Basque Government},
organization = {Regional Government of Murcia},
organization = {Regional Government of Navarra},
organization = {Instituto de Salud Carlos III Cooperative Research in Health (Spain)	RD06/0020},
organization = {Swedish Cancer Society		
Swedish Research Council},
organization = {County Council of Skane (Sweden)		
County Council of Vasterbotten (Sweden)},
organization = {Cancer Research UK	14136	
C570/A16491	
C8221/A19170},
organization = {UK Research & Innovation (UKRI)},
organization = {Medical Research Council UK (MRC)	1000143	
MR/M012190/1},
publisher = {Elsevier},
keywords = {Colorectal neoplasm},
keywords = {Risk factors},
keywords = {World Cancer Research Fund/American Institute for Cancer Research Recommendations},
keywords = {Targeted metabolomics},
title = {Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort},
doi = {10.1016/j.cgh.2020.11.045},
author = {Rothwell, Joseph A. and Sánchez Pérez, María José},
}