@misc{10481/75978,
year = {2022},
month = {6},
url = {http://hdl.handle.net/10481/75978},
abstract = {In this investigation, three new crystal forms of lidocaine, and another three of lidocaine
hydrochloride with hydroquinone, resorcinol, and pyrogallol were synthetised. All the new forms
were characterised using multiple techniques, PXRD, SC-XRD, DSC, and FTIR. The stability of the
forms was studied, and, for the more stable forms, i.e., (lidhcl) forms, the solubility was determined
through FTIR analysis. The new crystalline forms obtained with (lidhcl) and the three coformers
showed an interesting steric stabilisation mechanism of the oxidation of hydroxybenzenes and
showed good physicochemical properties with respect to (lidhcl), constituting a mechanism of
modulation of the physicochemical properties.},
organization = {Spanish Agencia Estatal de Investigacion of the Ministerio de Ciencia, Innovacion, y Universidades (MICIU) - FEDER, UE	PGC2018102047-B-I00
B-FQM-478-UGR20},
publisher = {MDPI},
keywords = {Lidocaine},
keywords = {Cocrystals},
keywords = {Mechanochemistry},
keywords = {Multicomponent materials},
keywords = {API},
keywords = {Pharmaceutical solids},
keywords = {Solubility},
title = {Lidocaine Pharmaceutical Multicomponent Forms: A Story about the Role of Chloride Ions on Their Stability},
doi = {10.3390/cryst12060798},
author = {Verdugo Escamilla, Cristóbal and Alarcón Payer, Carolina and Acebedo Martínez, Francisco Javier and Fernández Penas, Raquel and Domínguez Martín, Alicia and Choquesillo Lazarte, Duane},
}