@misc{10481/75922,
year = {2022},
month = {5},
url = {http://hdl.handle.net/10481/75922},
abstract = {Nowadays, there is an increasing interest in alternative therapies in the treatment of
metabolic syndrome that combine efficacy and safety profiles. Therefore, this study aimed to evaluate
the effect of an extract of Thymus serpyllum, containing rosmarinic acid, on high-fat diet (HFD)-
induced obesity mice, highlighting the impact of its antioxidant activity on the inflammatory status
and gut dysbiosis. The extract was administered daily (50, 100 and 150 mg/kg) in HFD-fed mice.
The treatment reduced body weight gain, glucose and lipid metabolic profiles. Moreover, the extract
ameliorated the inflammatory status, with the c-Jun N-terminal kinases (JUNK) pathway being
involved, and showed a significant antioxidant effect by the reduction of radical scavenging activity
and the mitigation of lipid peroxidation. Moreover, the extract was able to modulate the altered gut
microbiota, restoring microbial richness and diversity, and augmenting the counts of short-chain fatty
acid producing bacteria, which have been associated with the maintenance of gut permeability and
weight regulation. In conclusion, the antioxidant activity of Thymus serpyllum extract displayed a
positive impact on obesity and its metabolic alterations, also reducing systemic inflammation. These
effects may be mediated by modulation of the gut microbiota.},
organization = {Junta de Andalucia	CTS 164},
organization = {Instituto de Salud Carlos III
European Commission	PI19.01058},
organization = {Spanish Government	AGL201567995-C3-3-R},
organization = {European Commission},
organization = {Instituto de Salud Carlos III},
publisher = {MDPI},
keywords = {Thymus serpyllum},
keywords = {High fat diet},
keywords = {Obesity},
keywords = {Antioxidant},
keywords = {Anti-inflammatory},
keywords = {Gut microbiota},
title = {The Antioxidant Activity of Thymus serpyllum Extract Protects against the Inflammatory State and Modulates Gut Dysbiosis in Diet-Induced Obesity in Mice},
doi = {10.3390/antiox11061073},
author = {Ruiz Malagón, Antonio Jesús and Rodríguez Sojo, María Jesús and Hidalgo García, Laura and Molina Tijeras, José Alberto and García García, Federico and Romero Pérez, Miguel and Duarte Pérez, Juan Manuel and Díez Echave, Patricia and Rodríguez Cabezas, María Elena and Rodríguez Nogales, Alba and Gálvez Peralta, Julio Juan},
}