@misc{10481/75889,
year = {2021},
month = {8},
url = {http://hdl.handle.net/10481/75889},
abstract = {Background: Human leukocyte antigen (HLA) plays an important role in immune responses
to infections, especially in the development of acquired immunity. Given the high degree
of polymorphisms that HLA molecules present, some will be more or less effective in
controlling SARS-CoV-2 infection. We wanted to analyze whether certain polymorphisms may
be involved in the protection or susceptibility to COVID-19.
Methods: We studied the polymorphisms in HLA class I (HLA-A, -B and -C) and II (HLA-DRB1 and
HLA-DQB1) molecules in 450 patients who required hospitalization for COVID-19, creating one
of the largest HLA-typed patient cohort to date.
Results: Our results show that there is no relationship between HLA polymorphisms or haplotypes
and susceptibility or protection to COVID-19. Conclusion: Our results may contribute to resolve the contradictory data on the role of HLA
polymorphisms in COVID-19 infection.},
organization = {Instituto de Salud Carlos III - FEDER funds (European Union)	PI 16/00752},
organization = {Junta de Andalucia	CTS-143	
C-0013-2018},
organization = {RAFER S.L.},
publisher = {Elsevier},
keywords = {HLA polymorphisms},
keywords = {COVID-19},
keywords = {SARS-CoV-2},
title = {Study of HLA-A, -B, -C, -DRB1 and -DQB1 polymorphisms in COVID-19 patients},
doi = {10.1016/j.jmii.2021.08.009},
author = {Gutiérrez Bautista, Juan Francisco and Rodríguez Nicolás, Antonio and Rosales Castillo, Antonio and López Ruz, Miguel Ángel and Martín Casares, Antonia María and Fernández Rubiales, Alonso and Anderson, Per Olof and Garrido Torres-Puchol, Federico and Ruiz-Cabello Osuna, Francisco and López Nevot, Miguel Ángel},
}