@misc{10481/75884,
year = {2021},
month = {12},
url = {http://hdl.handle.net/10481/75884},
abstract = {The goal of this work is the design and the development of scaffolds based on maltodextrin (MD) to recover chronic
lesions. MD was mixed with arginine/lysine/polylysine and the electrospinning was successfully used to prepare scaffolds
with uniform and continuous nanofibers having regular shape and smooth surface. A thermal treatment was applied
to obtain insoluble scaffolds in aqueous environment, taking the advantage of amino acids-polysaccharide
conjugates formed via Maillard-type reaction. The morphological analysis showed that the scaffolds had nanofibrous
structures, and that the cross-linking by heating did not significantly change the nanofibers' dimensions and did not
alter the systemstability. Moreover, the heating process caused a reduction of free amino group and proportionally increased
scaffold cross-linking degree. The scaffolds were elastic and resistant to break, and possessed negative zeta potential
in physiological fluids. These were characterized by direct antioxidant properties and Fe2+ chelation capability
(indirect antioxidant properties). Moreover, the scaffolds were cytocompatible towards fibroblasts and monocytesderived
macrophages, and did not show any significant pro-inflammatory activity. Finally, those proved to accelerate
the recovery of the burn/excisional wounds. Considering all the features, MD-poly/amino acids scaffolds could be considered
as promising medical devices for the treatment of chronic wounds.},
organization = {Horizon 2020 Research and Innovation Programme	814607},
publisher = {Elsevier},
keywords = {Chronic wounds},
keywords = {Maltodextrin},
keywords = {Amino acids},
keywords = {Maillard-type reaction},
keywords = {Mechanical properties},
keywords = {Surface zeta potential},
keywords = {Immune response},
keywords = {Murine bum/excisional model},
title = {Maltodextrin-amino acids electrospun scaffolds cross-linked with Maillard-type reaction for skin tissue engineering},
doi = {10.1016/j.msec.2021.112593},
author = {Ruggeri, Marco and Sánchez Espejo, Rita María and Viseras Iborra, César Antonio},
}