@misc{10481/75877,
year = {2022},
month = {6},
url = {http://hdl.handle.net/10481/75877},
abstract = {Pharmacists may be tasked to lead antibiotic stewardship programmes (ASP) implementation in
small hospitals in absence of infectious diseases (ID) physicians. The objectives are to evaluate the
effectiveness of a pharmacist-led ASP in a hospital without ID physician support, with special focus on
indicators of the hospital use of antimicrobial agents based on consumption and asess the potential
clinical and economic impact of pharmacist interventions (PIs) through the CLEO tool. A prospective
quasi-experimental study to implement an ASP in a 194-bed hospital. We evaluated changes in
antimicrobial use measured as mean defined daily doses per 1000 patient-days (AUD) for intervention
versus preintervention period. A total of 847 antimicrobial PIs were proposed, being 88.3% accepted.
Discontinuation due to excessive duration was the most frequently performed PI (23.4%). Most of
PIs was classified as major or moderate clinical impact, 41.7% and 37.8% respectively. The global
consumption of antimicrobial was reduced from 907.1 to 693.8 AUD, with a signifcant drop in
carbapenems and quinolones. Direct expenditure of antibiotics decreased significantly. Pharmacistled
ASP has being effective in reducing consumption of antibiotics. In the absence of ID physician´s
support and oversight, pharmacists could lead the improvement of the use of antimicrobials.},
publisher = {Nature},
title = {Pharmacist‑led antimicrobial stewardship programme in a small hospital without infectious diseases physicians},
doi = {10.1038/s41598-022-13246-6},
author = {Cantudo Cuenca, María Rosa and Jiménez Morales, Alberto and Martínez de la Plata, Juan Enrique},
}