@misc{10481/75851,
year = {2022},
month = {6},
url = {http://hdl.handle.net/10481/75851},
abstract = {Pediatric acute myeloid leukemia (AML) is a rare and heterogeneous disease that remains
the major cause of mortality in children with leukemia. To improve the outcome of pediatric
AML we need to gain knowledge on the biological bases of this disease. NUP98-KDM5A
(NK5A) fusion protein is present in a particular subgroup of young pediatric patients with
poor outcome. We report the generation and characterization of human Embryonic Stem
Cell (hESC) clonal lines with inducible expression of NK5A. Temporal control of NK5A
expression during hematopoietic differentiation from hESC will be critical for elucidating its
participation during the leukemogenic process.},
organization = {Health
Institute Carlos III (ISCIII/FEDER, PI17/01574)},
publisher = {Frontiers},
keywords = {Acute myeliod leukemia},
keywords = {Pediatric},
keywords = {Disease model},
keywords = {Human stem cell},
keywords = {Hematopoieisis},
title = {Generation of a H9 Clonal Cell Line With Inducible Expression of NUP98-KDM5A Fusion Gene in the AAVS1 Safe Harbor Locus},
doi = {10.3389/fcell.2022.846092},
author = {Domingo Reinés, Joan and Martínez Navajas, Gonzalo and Montes, Rosa and Lamolda, Mar and Simón Sáez, Iris and Ríos Pelegrina, Rosa María and López Hidalgo, Javier Luis and García Del Moral Garrido, Raimundo and Marchal Corrales, Juan Antonio and Real Luna, Pedro José and Ramos Mejía, Verónica},
}