@misc{10481/75846,
year = {2022},
month = {6},
url = {http://hdl.handle.net/10481/75846},
abstract = {Basil is an aromatic herb with a high concentration of bioactive compounds. The oil extracted from its
seeds is a good source of α-linolenic acid (ALA) and also provides substantial amounts of linoleic acid
(LA). This study aimed to test the bioavailability of the oil derived from basil seeds and its effects on
different physiological parameters using 7–15% dietary inclusion levels. Furthermore, the assimilation of
LA and ALA and their transformation in long-chain polyunsaturated fatty acids (LC-PUFAs) have been
studied. Digestive utilization of total fat from basil seed oil (BSO) was high and similar to that of olive oil
used as a control. Consumption of BSO resulted in increased LA and ALA levels of the plasma, liver, and
erythrocyte membrane. In addition, the transformation of LA to arachidonic acid (ARA) was decreased by
the high dietary intake of ALA which redirected the pathway of the Δ-6 desaturase enzyme towards the
transformation of ALA into eicosapentaenoic acid (EPA). No alterations of hematological and plasma biochemical
parameters were found for the 7 and 10% dietary inclusion levels of BSO, whereas a decrease in
the platelet count and an increase in total- and HDL-cholesterol as well as plasma alkaline phosphatase
(ALP) were found for a 15% BSO dose. In conclusion, BSO is a good source of ALA to be transformed into
EPA and decrease the precursor of the pro-inflammatory molecule ARA. This effect on the levels of EPA
in different tissues offers potential for its use as a dietary supplement, novel functional food, or a constituent
of nutraceutical formulations to treat different pathologies.},
organization = {Spanish Government},
organization = {European Commission	PTQ-17-09172	
RTC-2017-6540-1	
RTI2018-100934-B-I00	
RTC2019-006870-1},
organization = {Andalusian Government	AGR145	
CTS164	
CTS-107},
publisher = {Royal Society of Chemistry},
title = {Bioavailability and biotransformation of linolenic acid from basil seed oil as a novel source of omega-3 fatty acids tested on a rat experimental model},
doi = {10.1039/d2fo00672c},
author = {Martínez Martínez, Rosario and Mesas Hernández, Cristina and Guzmán, Ana and Galisteo Moya, Milagros and López-Jurado Romero De La Cruz, María and Prados Salazar, José Carlos and Melguizo Alonso, Consolación and Porres Foulquie, Jesús María},
}