@misc{10481/75842,
year = {2022},
month = {6},
url = {http://hdl.handle.net/10481/75842},
abstract = {Organophosphate nerve agents and pesticides are extremely
toxic compounds because they result in acetylcholinesterase (AChE)
inhibition and concomitant nerve system damage. Herein, we report the
synthesis, structural characterization, and proof-of-concept utility of
zirconium metal−organic polyhedra (Zr-MOPs) for organophosphate
poisoning treatment. The results show the formation of robust tetrahedral
cages [((n-butylCpZr)3(OH)3O)4L6]Cl6 (Zr-MOP-1; L = benzene-1,4-
dicarboxylate, n-butylCp = n-butylcyclopentadienyl, Zr-MOP-10, and L =
4,4′-biphenyldicarboxylate) decorated with lipophilic alkyl residues and
possessing accessible cavities of ∼9.8 and ∼10.7 Å inner diameters,
respectively. These systems are able to both capture the organophosphate
model compound diisopropylfluorophosphate (DIFP) and host and release
the AChE reactivator drug pralidoxime (2-PAM). The resulting 2-PAM@
Zr-MOP-1(0) host−guest assemblies feature a sustained delivery of 2-PAM under simulated biological conditions, with a
concomitant reactivation of DIFP-inhibited AChE. Finally, 2-PAM@Zr-MOP systems have been incorporated into biocompatible
phosphatidylcholine liposomes with the resulting assemblies being non-neurotoxic, as proven using neuroblastoma cell viability
assays.},
organization = {Spanish MCIN/AEI	PID2020-113608RB-I00},
organization = {FEDER/Junta de Andalucia-Conserjeria de Economia y Conocimiento	B-FQM-364-UGR18	
B-FQM-006-UGR18},
organization = {FEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades	P18-RT-612	
P20_00672},
organization = {Fondazione CRUI},
organization = {programa Juan de la Cierva Formacion},
organization = {Spanish Government	PID2020-118117RB-I00},
organization = {Center for Forestry Research & Experimentation (CIEF)},
organization = {European Commission	SEJIGENT/2021/059	
PROMETEU/2021/054},
organization = {La Caixa Foundation	100010434	
LCF/BQ/PR20/11770014},
organization = {"Maria de Maeztu" Program for Centers of Excellence in RD	CEX2019-000919-M},
organization = {H2020-MSCA-IF2019-888972-PSust-MOF},
publisher = {American Chemical Society},
keywords = {Nerve agents},
keywords = {Host-guest chemistry},
keywords = {Pesticide},
keywords = {Controlled drug delivery},
keywords = {Metal-organic cages},
title = {Zirconium Metal−Organic Polyhedra with Dual Behavior for Organophosphate Poisoning Treatment},
doi = {10.1021/acsami.2c06025},
author = {Delgado López, Pedro José and Martín Romera, Javier David and Perona, Cristina and Vismara, Rebecca and Rodríguez Maldonado, Carmen and Carmona Fernández, Francisco Jesús and Rodríguez Navarro, Jorge Andrés},
}