@misc{10481/75715,
year = {2022},
month = {5},
url = {http://hdl.handle.net/10481/75715},
abstract = {Natural phenolic compounds have gained momentum for the prevention and treatment
of cancer, but their antitumoral mechanism of action is not yet well understood. In the present
study, we screened the antitumoral potential of several phenolic compounds in a cellular model of
colorectal cancer (CRC).We selected gallic acid (GA) as a candidate in terms of potency and selectivity
and extensively evaluated its biological activity. We report on the role of GA as a ligand of DNA
G-quadruplexes (G4s), explaining several of its antitumoral effects, including the transcriptional
inhibition of ribosomal and CMYC genes. In addition, GA shared with other established G4 ligands
some effects such as cell cycle arrest, nucleolar stress, and induction of DNA damage. We further
confirmed the antitumoral and G4-stabilizing properties of GA using a xenograft model of CRC.
Finally, we succinctly demonstrate that GA could be explored as a therapeutic agent in a patient
cohort with CRC. Our work reveals that GA, a natural bioactive compound present in the diet, affects
gene expression by interaction with G4s both in vitro and in vivo and paves the way towards G4s
targeting with phenolic compounds.},
organization = {Instituto de Salud Carlos III},
organization = {European Commission	PI21/00497
AC18/00008},
organization = {Next generation EU, Plan de Recuperacion Transformacion y Resiliencia, Agencia Estatal de Investigacion	PLEC2021-008094},
organization = {Ministerio de Ciencia e Innovacion from Government of Spain	PID2019-104416RB-I00
PID2020-120481RB-I00},
organization = {Ministerio de Universidades from Government of Spain	FPU16/05822
FPU17/05413
FPU20/03952},
organization = {University of Almeria	FPI-201102},
publisher = {MDPI},
keywords = {G-quadruplex},
keywords = {Phenol},
keywords = {Gallic acid},
keywords = {Cancer},
keywords = {Colorectal cancer},
title = {Gallic Acid: A Natural Phenolic Compound Exerting Antitumoral Activities in Colorectal Cancer via Interaction with G-Quadruplexes},
doi = {10.3390/cancers14112648},
author = {Sánchez Martín, Victoria and Plaza Calonge, María del Carmen and Soriano Lerma, Ana del Carmen and Ortiz González, Matilde and Linde Rodríguez, Ángel and Pérez Carrasco, Virginia and Ramírez Macías, Inmaculada and Cuadros Celorrio, Marta Eugenia and Gutiérrez Fernández, José and Murciano Calles, Javier and Rodríguez Manzaneque, Juan Carlos and Soriano, Miguel and García Salcedo, José Antonio},
}