@misc{10481/75688,
year = {2022},
month = {4},
url = {http://hdl.handle.net/10481/75688},
abstract = {Euphorbia lathyris seeds have been used to treat various medical conditions. We previously reported that
ethanolic extract from the defatted seed of Euphorbia lathyris (EE) (variety S3201) possesses a potent in vitro
antitumor activity against colon cancer (CRC) cell lines. However, the effects of EE on CRC in vivo models and its
possible preventive activity have not been elucidated. The aim of this study is to develop an in vivo study to
corroborate its efficacy. For this purpose, two tumor induction models have been developed. In orthotopic
xenograft model, it has been shown that EE reduces tumor size without hematological toxicity. The ethanolic
extract induced an intense apoptosis in tumors mediated by caspase 3. Using the Azoxymethane/Dextran Sulfate
Sodium model, a reduction of dysplastic polyps has been demonstrated, showing its preventive power.
Furthermore, EE promoted the presence of an eubiotic microbiotal environment in the mucosa of the colon and
induced an increase in antioxidant enzyme activity. This fact was accompanied by a modulation of cytokine
expression that could be related to its protective mechanism. Therefore, although further experiments will be
necessary to determine its applicability in the treatment of CRC, ES could be a new prevention strategy as well as
treatment for this type of tumor, being a powerful candidate for future clinical trials.},
organization = {Spanish Government	RTC-2017-6540-1	
RTC2019-006870-1},
organization = {Junta de Andalucia	P18-TP-1420},
organization = {European Commission	AGR145	
CTS-107},
organization = {Andalusian Government},
publisher = {Elsevier},
keywords = {Colon cancer},
keywords = {Euphorbia lathyris},
keywords = {AOM/DSS model},
keywords = {Orthotopic xenograft model},
keywords = {Oxidative stress detoxification enzymes},
keywords = {Microbiome},
title = {In vivo antitumor activity of Euphorbia lathyris ethanol extract in colon cancer models},
doi = {10.1016/j.biopha.2022.112883},
author = {Mesas Hernández, Cristina and Martínez Martínez, Rosario and Doello, Kevin and Ortiz Quesada, Raúl and López-Jurado Romero De La Cruz, María and Quiñonero Muñoz, Francisco José and Prados Salazar, José Carlos and Porres Foulquie, Jesús María and Melguizo Alonso, Consolación},
}