@misc{10481/75682,
year = {2022},
month = {5},
url = {http://hdl.handle.net/10481/75682},
abstract = {Corneal mechanical changes are believed to occur before any visible structural alterations observed
during routine clinical evaluation. This study proposed developing an elastography technique based
on torsional waves (TWE) adapted to the specificities of the cornea. By measuring the displacements
in the propagation plane perpendicular to the axis of the emitter, the effect of guided waves in platelike
media was proven negligible. Ex vivo experiments were carried out on porcine corneal samples
considering a group of control and one group of alkali burn treatment ( NH
4OH) that modified the
mechanical properties. Phase speed was recovered as a function of intraocular pressure (IOP), and a
Kelvin-Voigt rheological model was fitted to the dispersion curves to estimate viscoelastic parameters.
A comparison with uniaxial tensile testing with thin-walled assumptions was also performed. Both
shear elasticity and viscosity correlated positively with IOP, being the elasticity lower and the viscosity
higher for the treated group. The viscoelastic parameters ranged from 21.33 to 63.17 kPa, and from
2.82 to 5.30 Pa s, for shear elasticity and viscosity, respectively. As far as the authors know, no
other investigations have studied this mechanical plane under low strain ratios, typical of dynamic
elastography in corneal tissue. TWE reflected mechanical properties changes after treatment, showing
a high potential for clinical diagnosis due to its rapid performance time and paving the way for future
in vivo studies.},
organization = {Ministerio de Educacion, Cultura y Deporte Grant	DPI2017-83859-R	
DPI2014-51870-R	
UNGR15-CE-3664	
EQC2018-004508-P},
organization = {Spanish Government	DTS15/00093	
PI16/00339},
organization = {Instituto de Salud Carlos III y Fondos Feder},
organization = {Junta de Andalucia	PI-0107-2017	
PIN-0030-2017	
IE2017-5537},
organization = {MCIN/AEI - European Social Fund "Investing in your future"	PRE2018-086085},
organization = {Consejeria de economia, conocimiento, empresas y universidad	SOMM17/6109/UGR	
B-TEP-026- IE2017-5537	
P18-RT-1653},
organization = {European Commission	SOMM17/6109/UGR	
B-TEP-026- IE2017-5537	
P18-RT-1653},
publisher = {Nature},
title = {Torsional wave elastography to assess the mechanical properties of the cornea},
doi = {10.1038/s41598-022-12151-2},
author = {Torres Pérez, Jorge and Faris al Azzawi, Inas H and Callejas Zafra, Antonio Manuel and Melchor Rodríguez, Juan Manuel and Rus Carlborg, Guillermo},
}