@misc{10481/75497,
year = {2022},
month = {5},
url = {http://hdl.handle.net/10481/75497},
abstract = {Nanocomposites formed by clay and lipid carriers (NLCs) show a high potential for providing
controlled release and specific delivery of bioactive molecules and have recently gained attention
in the pharmaceutical sector due to their ability to transport hydrophilic and hydrophobic drugs.
Recent studies have recognized the biological activity of the oil of Bixa orellana L. (AO) with regards
to its healing, antioxidant, antibacterial, and anti-leishmanial properties. Therefore, the purpose
of this study is the preparation and characterization of hybrid systems based on lipid nanocarriers
and laponite for the delivery of AO. NLCs were prepared by the fusion-emulsification method,
using cetyl palmitate (CP) or myristyl myristate (MM), AO, and Poloxamer 188. The morphology,
hydrodynamic diameters, zeta potential (ZP), polydispersity index (PDI), thermal analysis, X-ray
diffraction analysis (XRD), viscosity behavior, and cytotoxicity testing of the hybrid systems were
performed. The thermal study and X-ray diffraction analyses (XRD) revealed polymorphic structural
changes compatible with the amorphization of the material. Rheological assays highlighted a typical
pseudoplastic behavior in all systems (MM and CP with LAP). The hybrid systems’ morphology, size
diameters, and PDIs were similar, preset spherical and monodisperse structures ( 200 nm; <0.3),
without significant change up to sixty days. The ZP values differed from each other, becoming higher
with increasing AO concentration. XEDS spectra and elemental X-ray maps show peaks of lipids
(organic components, C and O) and inorganic components O, Mg, and Si. All samples showed cell
viability above 60%. The results indicated a stable, biocompatible hybrid system that can be an
alternative for topical application.},
organization = {Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)	02817/09},
organization = {Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)},
organization = {Junta de Andalucia	PT18 RT 3786},
publisher = {MDPI},
keywords = {Hybrid system},
keywords = {Topical formulations},
keywords = {Colloidal suspension},
keywords = {Bixa orellana L.},
title = {Hybrid Lipid/Clay Carrier Systems Containing Annatto Oil for Topical Formulations},
doi = {10.3390/pharmaceutics14051067},
author = {De Melo Barbosa, Raquel and García Villén, Fátima and Sánchez Espejo, Rita María and Cerezo González, María Pilar and Viseras Iborra, César Antonio},
}