@misc{10481/75495,
year = {2022},
month = {5},
url = {http://hdl.handle.net/10481/75495},
abstract = {Objective: To investigate the association of plasma levels of endocannabinoids with fecal microbiota. Methods: Plasma levels of endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), as well as their eleven analogues, and arachidonic acid (AA), were measured using liquid chromatography-tandem mass spectrometry in 92 young adults. DNA extracted from stool samples was analyzed using 16S rRNA gene sequencing. Lipopolysaccharide levels were measured in plasma samples. Results: Plasma levels of endocannabinoids and their analogues were not related to beta or alpha diversity indexes. Plasma levels of AEA and related N-acylethanolamines correlated positively with the relative abundance of Faecalibacterium genus (all rho >= 0.26, p <= 0.012) and Akkermansia genus (all rho >= 0.22, p <= 0.036), and negatively with the relative abundance of Bilophila genus (all rho <= -0.23, p <= 0.031). Moreover, plasma levels of 2-AG and other acylglycerols correlated positively with the relative abundance of Parasutterella (all rho >= 0.24, p <= 0.020) and Odoribacter genera (all rho >= 0.27, p <= 0.011), and negatively with the relative abundance of Prevotella genus (all rho <= -0.24, p <= 0.023). In participants with high lipopolysaccharide values, the plasma levels of AEA and related N-acylethanolamines, as well as AA and 2-AG, were negatively correlated with plasma levels of lipopolysaccharide (all rho <= -0.24, p <= 0.020). Conclusion: Plasma levels of endocannabinoids and their analogues are correlated to specific fecal bacterial genera involved in maintaining gut barrier integrity in young adults. This suggests that plasma levels of endocannabinoids and their analogues may play a role in the gut barrier integrity in young adults.},
organization = {Spanish Ministry of Economy and Competitiveness via Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III	PI13/01393	
PTA 12264-I	
DEP2016-79512-R},
organization = {European Commission		
Spanish Government	FPU16/05159	
FPU16/02828	
FPU17/01523},
organization = {Fundacion Iberoamericana de Nutricion (FINUT)},
organization = {Redes Tematicas De Investigacion Cooperativa RETIC	Red SAMID RD16/0022},
organization = {China Scholarship Council	201707060012},
organization = {InFLAMES Flagship Programme of the Academy of Finland	337530},
organization = {Ministerio de Universidades y la Union Europea-NextGenerationEU	RR_C_2021_04},
organization = {AstraZeneca},
organization = {University of Granada Plan Propio de Investigacion 2016-Excellence actions: Unit of Excellence on Exercise and Health (UCEES)},
organization = {Junta de Andalucia	P18-RT-4455},
organization = {European Commission through the "European funds for regional development" (EFRE)},
organization = {regional Ministry of Economy, Science and Digitalization of Saxony-Anhalt as part of the "Autonomy in old Age" (AiA) research group for "LiLife" Project	ZS/2018/11/95324},
organization = {Consejeria de Economia, Industria, Conocimiento Universidades (PAIDI 2020, Junta de Andalucia), Spain	DOC_00448},
organization = {European Commission},
organization = {Spanish Government},
organization = {MIRACUM},
organization = {Federal Ministry of Education & Research (BMBF)	FKZ 01ZZ1801H},
publisher = {MDPI},
keywords = {Endocannabinoid system},
keywords = {Gut barrier},
keywords = {Gastrointestinal microbiome},
keywords = {Inflammation},
keywords = {Short-chain fatty acids},
title = {Plasma Levels of Endocannabinoids and Their Analogues Are Related to Specific Fecal Bacterial Genera in Young Adults: Role in Gut Barrier Integrity},
doi = {10.3390/nu14102143},
author = {Ortiz Álvarez, Lourdes and Xu, Huiwen and Osuna Prieto, Francisco Javier and Acosta, Francisco M. and Plaza Díaz, Julio and Gil Hernández, Ángel and Ruiz Ruiz, Jonatan and Martínez Téllez, Borja Manuel},
}