@misc{10481/75331,
year = {2022},
month = {5},
url = {http://hdl.handle.net/10481/75331},
abstract = {In conclusion, this study confirmed the association of 31 GWASidentified
SNPs with CLL risk and shed some light on the function
of some of these biomarkers in the modulation of TReg, B, and T
cell differentiation and proliferation, blood concentrations of B
cell-related proteins, cell survival, and the expression of immuneand
non-immune-related loci. Though outside the scope of the
current study, it is important to mention that additional functional
studies using blood samples from CLL patients are still required to
validate our findings and to decipher the exact biological
mechanisms behind the observed associations. A potential
limitation of this work was the relatively small population size of
the CRuCIAL cohort that hampered the validation of the SNPs
showing modest associations.},
organization = {European Union's Horizon 2020 research and innovation program	856620},
organization = {Instituto de Salud Carlos III	PI17/02256	
PI20/01845},
organization = {Consejeria de Economia, Conocimiento, Empresas y Universidad (Granada, Spain)	A-CTS-448-UGR18	
Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades (Sevilla, Spain)	PY20/01282},
organization = {Generalitat de Catalunya},
organization = {General Electric	17SGR437},
organization = {Gilead Sciences	GLD17/00282},
organization = {"Xarxa de Bancs de tumors" - Pla Director d'Oncologia de Catalunya (XBTC)},
organization = {Fondazione AIRC per la ricerca sul cancro		
Fondazione Cariplo	TRIDEO 16923	
AIRC IG21436},
organization = {Spanish Association Against Cancer (AECC) Scientific Foundation grant	GCTRA18022MORE},
organization = {Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), action Genrisk},
publisher = {Nature},
title = {Validation and functional characterization of GWAS-identified variants for chronic lymphocytic leukemia: a CRuCIAL study},
doi = {10.1038/s41408-022-00676-8},
author = {García Martín, Paloma and Moñiz Díez, Ana and Sánchez Maldonado, José Manuel and Cabrera Serrano, Antonio José and Hernández Mohedo, Francisca and González Sierra, Pedro Antonio and Cañadas Garre, Marisa and López Nevot, Miguel Ángel and Jurado Chacón, Manuel and Sáinz Pérez, Juan},
}