@misc{10481/75293,
year = {2022},
month = {4},
url = {http://hdl.handle.net/10481/75293},
abstract = {Background: Endogenous sex hormonesmay contribute to higher
colorectal cancer incidence rates in men compared with women, but
despite an increased number of studies, clear evidence is lacking.
Methods: We conducted a comprehensive nested case–control
study of circulating concentrations of sex hormones, sex hormone
precursors, and sex hormone binding globulin (SHBG) in relation to
subsequent colon cancer risk in European men. Concentrations
were measured using liquid LC/MS-MS in prospectively collected
plasma samples from 690 cases and 690 matched controls from the
European Prospective Investigation into Cancer and Nutrition
(EPIC) andtheNorthern SwedenHealth and Disease Study (NSHDS)
cohorts. Multivariable conditional logistic regression was used to
estimate odds ratios (OR) and 95% confidence intervals (CI). In
addition, we conducted a meta-analysis of previous studies on men.
Results: Circulating levels of testosterone (OR, 0.68; 95% CI,
0.51–0.89) and SHBG (OR, 0.77; 95% CI, 0.62–0.96) were inversely
associated with colon cancer risk. For free testosterone, there was a
nonsignificant inverse association (OR, 0.83; 95% CI, 0.58–1.18). In
a dose–response meta-analysis of endogenous sex hormone levels,
inverse associations with colorectal/colon cancer risk were found
for testosterone [relative risks (RR) per 100 ng/dL ¼ 0.98; 95% CI,
0.96–1.00; I2 ¼ 22%] and free testosterone (RR per 1 ng/dL ¼ 0.98;
95% CI, 0.95–1.00; I2 ¼ 0%).
Conclusions: Our results provide suggestive evidence for the
association between testosterone, SHBG, and male colon cancer
development.
Impact: Additional support for the involvement of sex hormones
in male colon cancer.},
organization = {Cancer foundation in Northern Sweden	AMP 17-856	
AMP 18-915	
AMP 19-967},
organization = {Lions Cancer Research Fund in Northern Sweden	LP 20-2227},
organization = {Department of Radiation Sciences, Umea University},
organization = {NIHR Imperial Biomedical Research Centre (BRC)},
organization = {Danish Cancer Society},
organization = {Ligue nationale contre le cancer},
organization = {IARC},
organization = {Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London},
organization = {Institut Gustave Roussy, MutuelleGenerale de l'Education Nationale},
organization = {Institut National de la Sante et de la Recherche Medicale (Inserm)},
organization = {Deutsche Krebshilfe},
organization = {Helmholtz Association},
organization = {German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE)},
organization = {Federal Ministry of Education & Research (BMBF)},
organization = {Fondazione AIRC per la ricerca sul cancro},
organization = {Compagnia di San Paolo},
organization = {Consiglio Nazionale delle Ricerche (CNR)},
organization = {Netherlands Government		
Netherlands Government},
organization = {World Cancer Research Fund International (WCRF)},
organization = {Netherlands Government},
organization = {Health Research Fund (FIS) -Instituto de Salud Carlos III (ISCIII) (Spain)},
organization = {Junta de Andalucia},
organization = {Principality of Asturias},
organization = {Regional Government of Basque Country (Spain)		
Regional Government of Murcia (Spain)		
Regional Government of Navarra (Spain)		
Catalan Institute of Oncology -ICO (Spain)},
organization = {Swedish Cancer Society		
Swedish Research Council		
Region of Skane (Sweden)		
Region of Vasterbotten (Sweden)},
organization = {Cancer Research UK	14136	
C8221/A29017	
UK Research & Innovation (UKRI)},
organization = {Medical Research Council UK (MRC)},
organization = {European Commission	1000143	
MR/M012190/1},
organization = {Swedish Research Council},
organization = {European Commission	VR 2017-00650},
publisher = {American Association for Cancer Research},
title = {Circulating Sex Hormone Levels and Colon Cancer Risk in Men: A Nested Case–Control Study and Meta-Analysis},
doi = {10.1158/1055-9965.EPI-21-0996},
author = {Harbs, Justin and Sánchez Pérez, María José},
}