@misc{10481/75291,
year = {2022},
month = {3},
url = {http://hdl.handle.net/10481/75291},
abstract = {Background & aims: Menopausal hormonal changes increase the risk of deficiencies of minerals such as zinc (Zn),
which could further worsen the decreased antioxidant defense of postmenopausal women. This study assesses the
effect of 8 weeks of Zn supplementation upon the antioxidant status and clinical nutritional parameters of a
postmenopausal population.
Methods: Fifty-one postmenopausal women were divided into two groups: placebo (PbG) and zinc supplementation
(ZnG). Mineral status was determined by Flame Atomic Absorption Spectrophotometry (FAAS). Total
Antioxidant Capacity (TAC) and Superoxide Dismutase (SOD) were analyzed by kinetic colorimetric methods.
Glutathione Peroxidase (GPx) was assessed by an enzymatic immunological method.
Results: Poor Zn status was initially observed in erythrocyte samples. Total antioxidant capacity showed a significant
correlation (r = 0.730; p < 0.05) to erythrocyte Zn after the intervention (ZnG: r = 0.96; p < 0.001).
Moreover, erythrocyte Zn concentration in ZnG was positively correlated to GPx activity after the intervention (r
= 0.61; p < 0.01).
Conclusions: The postmenopausal women initially presented Zn deficiency, and the status of this mineral
improved after the intervention. Zinc supplementation may be an effective approach for correcting the observed
deficiencies, enhancing antioxidant defense in this risk population.},
organization = {Zinc-Net-The Network for
the Biology of Zinc (FA COST Action TD1304)},
organization = {FIS Project from
Carlos III Health Institute [REF.PI10/1993]},
organization = {FPU fellowship from the Spanish Ministry
of Education},
publisher = {Elsevier},
keywords = {Postmenopausal women},
keywords = {Antioxidant status},
keywords = {Zinc},
keywords = {Supplementation},
keywords = {Total antioxidant capacity},
title = {Erythrocyte Zn concentration and antioxidant response after supplementation with Zn in a postmenopausal population. A double-blind randomized trial},
doi = {10.1016/j.exger.2022.111766},
author = {Vázquez Lorente, Héctor and Molina López, Jorge and Herrera Quintana, Lourdes María and Gamarra Morales, Yenifer and Quintero Osso, Bartolomé and López González, Beatriz and Planells Del Pozo, Elena María},
}