@misc{10481/75137,
year = {2022},
month = {4},
url = {http://hdl.handle.net/10481/75137},
abstract = {Western diet, high in fats and sugars and low in greens, contributes to dysbiosis of the
gut microbiota, which can lead to a variety of chronic diseases related with inflammation.
Supplementation with bioactive compounds can help to maintain a healthy eubiotic
state. Thus, we performed a 4-weeks nutritional intervention on healthy volunteers to
investigate whether a blend of natural tannin extracts could induce healthy changes
in the microbial intestinal ecosystem. Changes in the composition and functionality
of the microbiota could be observed from the first two weeks onward. 16S rRNA
amplicon next-generation sequencing (NGS) revealed a significant increase in microbial
diversity at the end of the intervention, as well as trends toward increases in the
relative abundances of several beneficial taxa, such as Ruminococcus bicirculans,
Faecalibacterium prausnitzii, Lachnospiraceae UCG 010, Lachnospiraceae NK4A136,
Bacteroides thetaiotaomicron and B. uniformis. Remarkably, some of the identified taxa
were also identified as responsible for an increase in the production of short-chain fatty
acids (SCFAs), microbial metabolites that contribute to the modulation of the immune
system and have various other anti-inflammatory functions in the gut. Taken together,
these results suggest that the tannin supplementation could exert a prebiotic effect by
selectively stimulating the growth and the activity of bacteria that are advantageous for
the host.},
organization = {research project Stance4Health from the European Commission (Research Executive Agency)	816303},
publisher = {Frontiers},
keywords = {Tannins},
keywords = {Quebracho},
keywords = {Gall oak},
keywords = {Gut microbiota},
keywords = {Short-chain fatty acids},
title = {Evaluation of the Effects of a Short Supplementation With Tannins on the Gut Microbiota of Healthy Subjects},
doi = {10.3389/fmicb.2022.848611},
author = {Molino, Silvia and Rufián Henares, José Ángel},
}