@misc{10481/74983,
year = {2022},
month = {5},
url = {http://hdl.handle.net/10481/74983},
abstract = {In species with seasonal breeding, male specimens undergo substantial testicular
regression during the nonbreeding period of the year. However, the molecular
mechanisms that control this biological process are largely unknown. Here, we
report a transcriptomic analysis on the Iberian mole, Talpa occidentalis, in which the
desquamation of live, nonapoptotic germ cells is the major cellular event responsible
for testis regression. By comparing testes at different reproductive states (active,
regressing, and inactive), we demonstrate that the molecular pathways controlling
the cell adhesion function in the seminiferous epithelium, such as the MAPK, ERK,
and TGF‐β signaling, are altered during the regression process. In addition, inactive
testes display a global upregulation of genes associated with immune response,
indicating a selective loss of the “immune privilege” that normally operates in
sexually active testes. Interspecies comparative analyses using analogous data from
the Mediterranean pine vole, a rodent species where testis regression is controlled
by halting meiosis entry, revealed a common gene expression signature in the
regressed testes of these two evolutionary distant species. Our study advances in
the knowledge of the molecular mechanisms associated to gonadal seasonal
breeding, highlighting the existence of a conserved transcriptional program of testis
involution across mammalian clades.},
organization = {Spanish Secretaria de Estado de Investigacion, Desarrollo e Innovacion, Ministerio de Econimia y Competitividad	CGL-2015-67108-P},
organization = {Junta de Andalucia	BIO109},
organization = {German Research Foundation (DFG)	MU 880/15-1	
MU 880/27-1},
organization = {Helmholtz ERC Recognition Award		
Helmholtz Association	ERC-RA-0033},
publisher = {Wiley},
keywords = {Cell adhesion},
keywords = {Immune response},
keywords = {Microtus duodecimcostatus},
keywords = {Seasonal reproduction},
keywords = {Seasonal testis regression},
keywords = {Talpa occidentalis},
keywords = {Testis transcriptome},
title = {Cell adhesion and immune response, two main functions altered in the transcriptome of seasonally regressed testes of two mammalian species},
doi = {10.1002/jez.b.23142},
author = {Real, Francisca M. and Lao Pérez, Miguel and Burgos Poyatos, Miguel and Jiménez Medina, Rafael and Barrionuevo Jiménez, Francisco Javier},
}