@misc{10481/74848,
year = {2022},
month = {4},
url = {http://hdl.handle.net/10481/74848},
abstract = {The fetus depends on the transplacental transfer of vitamin D. Calcifediol (25-OH-D3) is
the vitamin D metabolite that crosses the placenta. Previously, oral 25-OH-D3 improved
serum 25-OH-D3 compared to vitamin D3 in non-pregnant subjects, although no
studies are available in pregnant women. We evaluated the availability of oral 25-OH-D3
compared to vitamin D3 during pregnancy, as well as, their levels in the fetus and effect
on metabolism-related proteins. Twenty female rats per group were fed with 25 mg/kg
of diet of vitamin D3 (1,000 UI vitamin D/kg diet) or with 25 mg/kg diet of 25-OH-D3.
We analyzed 25-OH-D3 levels in maternal and fetal plasma; protein levels of vitamin
D receptor (VDR), fatty acid translocase (FAT), and scavenger-receptor class B type-1
(SR-B1) in both maternal liver and placenta; and protein levels of VDR and Glutamate
decarboxylase (GAD67) in fetal brain. 25-OH-D3 doubled the concentration of 25-OHD3
in both maternal and fetal plasma compared to vitamin D3. In addition, maternal liver
VDR, FAT, and SR-BI increased significantly in the 25-OH-D3 group, but no changes
were found in the placenta. Interestingly, 25-OH-D3 decreased GAD67 expression in
the fetal brain and it also tended to decrease VDR (P = 0.086). In conclusion, 25-OHD3
provided better vitamin D availability for both mother and fetus when administered
during pregnancy compared to vitamin D3. No adverse effects on pregnancy outcomes
were observed. The effects of 25-OH-D3 on the expression of VDR and GAD67 in fetal
brain require further investigation.},
organization = {Abbott Nutrition S.L.},
publisher = {Frontiers},
keywords = {Availability},
keywords = {Calcidiol},
keywords = {Calcfediol},
keywords = {Pregnancy},
keywords = {Vitamin D},
title = {Calcifediol During Pregnancy Improves Maternal and Fetal Availability of Vitamin D Compared to Vitamin D3 in Rats and Modifies Fetal Metabolism},
doi = {10.3389/fnut.2022.871632},
author = {Gázquez, Antonio and Barranco Pérez, Alejandro and Rueda, Ricardo},
}