@misc{10481/74824,
year = {2022},
month = {1},
url = {http://hdl.handle.net/10481/74824},
abstract = {Glucocorticoids (GCs) are widely used drugs for their anti-inflammatory and immunosuppressant effects, but
they are associated with multiple adverse effects. Despite their frequent oral administration, relatively little
attention has been paid to the effects of GCs on intestinal barrier function. In this review, we present a summary
of the published studies on this matter carried out in animal models and cultured cells. In cultured intestinal
epithelial cells, GCs have variable effects in basal conditions and generally enhance barrier function in the
presence of inflammatory cytokines such as tumor necrosis factor (TNF). In turn, in rodents and other animals,
GCs have been shown to weaken barrier function, with increased permeability and lower production of IgA,
which may account for some features observed in stress models. When given to animals with experimental colitis,
barrier function may be debilitated or strengthened, despite a positive anti-inflammatory activity. In sepsis
models, GCs have a barrier-enhancing effect. These effects are probably related to the inhibition of epithelial cell
proliferation and wound healing, modulation of the microbiota and mucus production, and interference with the
mucosal immune system. The available information on underlying mechanisms is described and discussed.},
organization = {"Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Spain},
organization = {Ministry of Economy and Competitivity},
organization = {European Commission	SAF2017-88457-R	
AGL2017-85270-R},
organization = {Junta de Andalucia
European Commission	CTS235	
CTS164},
organization = {Instituto de Salud Carlos III	PI19/00819},
organization = {European Regional Development Fund/European Social Fund, "Investing in your future"},
organization = {Junta de Castilla y Leon	SA074P20},
organization = {Fundacio Marato TV3, Spain	201916-31},
organization = {AECC Scientific Foundation, Spain},
organization = {"Centro Internacional sobre el Envejecimiento" (OLD-HEPAMARKER), Spain	0348_CIE_6_E},
organization = {Ministry of Education},
organization = {CIBERehd},
organization = {Universidad de Granada/CBUA},
publisher = {Elsevier},
keywords = {Glucocorticoid},
keywords = {Intestinal barrier function},
keywords = {IgA},
keywords = {Colitis},
keywords = {Stress},
title = {Modulation of intestinal barrier function by glucocorticoids: Lessons from preclinical models},
doi = {10.1016/j.phrs.2022.106056},
author = {Tena Garitaonaindia, Mireia and Arredondo Amador, María and Mascaraque Molina, Cristina and Martínez Augustín, María Olga and Sánchez De Medina López-Huertas, Fermín},
}