@misc{10481/74793,
year = {2022},
month = {4},
url = {http://hdl.handle.net/10481/74793},
abstract = {Hyaluronic acid (HA), through its interactions with the cluster of differentiation 44 (CD44),
acts as a potent modulator of the tumor microenvironment, creating a wide range of extracellular
stimuli for tumor growth, angiogenesis, invasion, and metastasis. An innovative antitumor treatment
strategy based on the development of a nanodevice for selective release of an inhibitor of the HACD44
interaction is presented. Computational analysis was performed to evaluate the interaction of
the designed tetrahydroisoquinoline-ketone derivative (JE22) with CD44 binding site. Cell viability,
efficiency, and selectivity of drug release under acidic conditions together with CD44 binding
capacity, effect on cell migration, and apoptotic activity were successfully evaluated. Remarkably, the
conjugation of this CD44 inhibitor to the nanodevice generated a reduction of the dosis required to
achieve a significant therapeutic effect.},
organization = {Junta de Andalucia	P18-RT-1679},
organization = {Research Results Transfer Office (OTRI) of the University of Granada	PR/17/006},
organization = {Spanish Government	PID2019.110987RB.I00},
organization = {Health Institute Carlos III (ISCIII)	DTS18/00121},
organization = {Junta de Andalucia-FEDER, Ministry of Economy, Knowledge, Companies, and University (FEDER)	B-FQM-475-UGR18	
PT18-TP-4160},
organization = {Andalusian Regional Government	POSTDOC_21_00118},
organization = {UK Research & Innovation (UKRI)},
organization = {Engineering & Physical Sciences Research Council (EPSRC)	EP/L000253/1},
organization = {European Union's Horizon 2020 Research and Innovation Program under Marie Sklodowska-Curie Grant	754446},
organization = {UGR Research and Knowledge Transfer Fund-Athenea3i},
organization = {Spanish Government	FPU 16/02061},
publisher = {MDPI},
keywords = {Nanomedicine},
keywords = {Selective release},
keywords = {Anticancer therapy},
keywords = {Hyaluronic acid},
keywords = {Cluster of differentiation 44},
keywords = {Tetrahydroisoquinoline},
keywords = {Molecular dynamics simulations},
title = {Selective Anticancer Therapy Based on a HA-CD44 Interaction Inhibitor Loaded on Polymeric Nanoparticles},
doi = {10.3390/pharmaceutics14040788},
author = {Espejo Román, José Manuel and Rubio Ruiz, Belén and Cano Cortes, María Victoria and Cruz López, Olga María and Conejo García, Ana and Sánchez Martín, Rosario María},
}