@misc{10481/74785,
year = {2022},
month = {4},
url = {http://hdl.handle.net/10481/74785},
abstract = {The stereo- and regioselective total syntheses of OMe derivatives of the scarce bioactive
meroterpenoids makassaric acid (1) and fascioquinol B (2) have been accomplished. The synthetic
sequences are based on the following three efficient and selective catalytic reactions: Cu-catalyzed
addition of Grignard compounds to an epoxide; a regioselective Barbier-type reaction, catalyzed by
Cp2TiCl; and regio- and stereoselective bioinspired cyclization, also catalyzed by Cp2TiCl. These three
key processes allow us to obtain the main skeletons of 1 and 2 in a few steps. The valuable synthetic
proposal shown in this work provides fast access to scarce, structurally complex meroterpenes with
promising biological activities, which are a sustainable source for later studies and applications
in medicine.},
organization = {FEDER (EDRF)/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades	P18-FR-2877
A-FQM-079-UGR18},
publisher = {MDPI},
keywords = {Terpenes},
keywords = {Natural product},
keywords = {Titanocene},
keywords = {Synthetic methods},
keywords = {Radicals},
title = {Exploring Short and Efficient Synthetic Routes Using Titanocene(III)-Catalyzed Reactions: Total Synthesis of Natural Meroterpenes with Trisubstituted Unsaturations},
doi = {10.3390/molecules27082400},
author = {Rosales, Jennifer and Justicia Ladrón De Guevara, José},
}