@misc{10481/74771,
year = {2022},
month = {4},
url = {http://hdl.handle.net/10481/74771},
abstract = {Bone fragility is a common complication in subjects with type 2 diabetes mellitus (T2DM).
However, traditional techniques for the evaluation of bone fragility, such as dual-energy X-ray absorptiometry
(DXA), do not perform well in this population. Moreover, the Fracture Risk Assessment
Tool (FRAX) usually underestimates fracture risk in T2DM. Importantly, novel technologies for the
assessment of one microarchitecture in patients with T2DM, such as the trabecular bone score (TBS),
high-resolution peripheral quantitative computed tomography (HR-pQCT), and microindentation,
are emerging. Furthermore, different serum and urine bone biomarkers may also be useful for
the evaluation of bone quality in T2DM. Hence, in this article, we summarize the limitations of
conventional tools for the evaluation of bone fragility and review the current evidence on novel
approaches for the assessment of quality and bone microstructure alterations in patients with T2DM.},
organization = {Instituto de Salud Carlos III},
organization = {European Commission	CD20/00022	
European Commission},
organization = {Junta de Andalucia	PI-0268-2019},
publisher = {MDPI},
keywords = {Type 2 diabetes mellitus},
keywords = {Bone fragility},
keywords = {Fracture risk},
keywords = {Bone structure},
keywords = {Bone quality},
title = {Evaluation of Quality and Bone Microstructure Alterations in Patients with Type 2 Diabetes: A Narrative Review},
doi = {10.3390/jcm11082206},
author = {Martínez Montoro, José Ignacio and García Fontana, Beatriz and García Fontana, Cristina and Muñoz Torres, Manuel Eduardo},
}